Filtered By:
Source: Free Radical Biology and Medicine

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 199 results found since Jan 2013.

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system.
In conclusion, we demonstrated that CA prevented APAP-induced hepatotoxicity by decreasing Keap1 expression, inhibiting binding of Keap1 to Nrf2, and thus activating Nrf2 and leading to increased expression of antioxidative signals including HO-1 and NQO1. PMID: 26721592 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - December 23, 2015 Category: Biology Authors: Pang C, Zheng Z, Shi L, Sheng Y, Wei H, Wang Z, Ji L Tags: Free Radic Biol Med Source Type: research

Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase.
Abstract Peroxiredoxin-3 (Prx3) accounts for about 90% of mitochondrial peroxidase activity, and its marked upregulation in many cancers is important for cell survival. Prx3 oxidation can critically alter peroxide signaling and defense and can be a seminal event in promoting cell death. Here it is shown that this mechanism can be exploited pharmacologically by combinations of clinically available drugs that compromise Prx3 function in different ways. Clinically relevant levels of the thiosemicarbazone iron chelators triapine (Tp) and 2,2'-Dipyridyl-N,N-dimethylsemicarbazone (Dp44mT) promote selective oxidation of ...
Source: Free Radical Biology and Medicine - December 11, 2015 Category: Biology Authors: Myers CR Tags: Free Radic Biol Med Source Type: research

Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction.
In conclusion, we demonstrate that arsenite acutely inhibits eNOS enzymatic activity and vessel relaxation in part by increasing the RhoA/CRIK/eNOS-Thr(497) phosphorylation signaling axis, which provides a molecular mechanism underlying arsenite-induced impaired vascular diseases. PMID: 26593676 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - November 16, 2015 Category: Biology Authors: Seo J, Cho DH, Lee HJ, Sung MS, Young Lee J, Won KJ, Park JH, Jo I Tags: Free Radic Biol Med Source Type: research

DHA-induced stress response in human colon cancer cells-focus on oxidative stress and autophagy.
Abstract Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n-3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have been well documented in relation to several diseases. Increasing evidence suggests that n-3 PUFAs may have anticancer activity and improve the effect of conventional cancer therapy. The mechanisms behind these effects are still unclear and need to be elucidated. We have examined the DHA-induced stress response in two human colon cancer cell lines, SW620 and Caco-2. SW620 cells are growth-inhibited a...
Source: Free Radical Biology and Medicine - November 13, 2015 Category: Biology Authors: Pettersen K, Monsen VT, Hakvåg Pettersen CH, Overland HB, Pettersen G, Samdal H, Tesfahun AN, Lundemo AG, Bjørkøy G, Schønberg S Tags: Free Radic Biol Med Source Type: research

Glutathione-S-transferase omega 1 (GSTO1-1) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis-autophagy crosstalk in macrophages.
Abstract Aflatoxin B1 (AFB1) is the most toxic aflatoxin species and has been shown to be associated with specific as well as non-specific immune responses. In the present study, using murine macrophage Raw 264.7 cells as a model, we report that short exposure (6h) to AFB1 caused an increase in the cellular calcium pool in mitochondria, which in turn elevated reactive oxygen species (ROS)-mediated oxidative stress and led to loss of mitochondrial membrane potential and ultimately c-Jun N-terminal kinases (JNK)-mediated caspase-dependent cell death. On the contrary, longer exposure (12h) to AFB1 reduced JNK phospho...
Source: Free Radical Biology and Medicine - November 9, 2015 Category: Biology Authors: Paul S, Jakhar R, Bhardwaj M, Kang SC Tags: Free Radic Biol Med Source Type: research

Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout mice.
CONCLUSIONS: The inhibitory effects of H2 on the apoptosis of macrophage-derived foam cells, which take effect by suppressing the activation of ERS pathway and by activating Nrf2 antioxidant pathway, might lead to an improvement in atherosclerotic plaque stability. PMID: 26117323 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - June 24, 2015 Category: Biology Authors: Song G, Zong C, Zhang Z, Yu Y, Yao S, Jiao P, Tian H, Zhai L, Zhao H, Tian S, Zhang X, Wu Y, Sun X, Qin S Tags: Free Radic Biol Med Source Type: research

c-jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells.
Abstract Tumor necrosis factor-α (TNFα), a pro-inflammatory cytokine, causes vascular smooth muscle cell (VSMC) proliferation and migration and promotes inflammatory vascular lesions. Nuclear factor-kappa B (NF-κB) activation by TNFα requires endosomal superoxide production by Nox1. In endothelial cells, TNFα stimulates c-Jun N-terminal kinase (JNK), which inhibits NF-κB signaling. The mechanism by which JNK negatively regulates TNFα-induced NF-κB activation has not been defined. We hypothesized that JNK modulates NF-κB activation in VSMC, and does so via a Nox1-dependent mechanism. TNFα-induced NF-κB a...
Source: Free Radical Biology and Medicine - May 19, 2015 Category: Biology Authors: Choi H, Dikalova A, Stark RJ, Lamb FS Tags: Free Radic Biol Med Source Type: research

UCP2 inhibition sensitizes breast Cancer cells to therapeutic agents by increasing oxidative stress.
In conclusion, UCP2 could be a therapeutic target in breast cancer, especially in those patients treated with tamoxifen. PMID: 25960046 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 7, 2015 Category: Biology Authors: Pons DG, Nadal-Serrano M, Torrens-Mas M, Valle A, Oliver J, Roca P Tags: Free Radic Biol Med Source Type: research

The superoxide dismutase 1 (SOD1) 3'UTR maintains High expression of the SOD1 gene in Cancer cells: The involvement of the RNA binding protein AUF1.
In this study, a full-length 3'UTR of the SOD1 transcript was cloned and characterized for its ability to regulate SOD1 gene expression in human cancer cells. Inclusion of the SOD1 3'UTR in the pGL3 reporter construct dramatically enhanced the reporter activity by 10-220-fold in various cell lines. RT-PCR analysis, however, indicated that the reporter gene mRNA levels were only modestly altered by the SOD1 3'UTR, suggesting that SOD1 3'UTR enhances the reporter gene activity not simply by stabilizing the mRNA but primarily through promoting translation of the protein. Bioinformatics analysis showed multiple stem and loop s...
Source: Free Radical Biology and Medicine - April 20, 2015 Category: Biology Authors: Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ Tags: Free Radic Biol Med Source Type: research

The Involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
Abstract Quercetin, one of the most abundant dietary flavonoids, is reported to have protective function against various hepatotoxicants-induced hepatotoxicity. The present study aims to investigate the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidative signaling pathway in the protection of quercetin against hepatotoxicity. Quercetin prevented the cytotoxicity induced by a variety of hepatotoxicants including clivorine (Cliv), acetaminophen (APAP), ethanol, carbon tetrachloride (CCl4), and toosendanin (TSN) in human normal liver L-02 cells. Quercetin induced the nuclear translocatio...
Source: Free Radical Biology and Medicine - April 13, 2015 Category: Biology Authors: Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT Tags: Free Radic Biol Med Source Type: research

4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes.
Abstract 4-Hydroxy-2-nonenal (HNE) is a highly cytotoxic product of lipid peroxidation. Nevertheless, at low concentrations, it is able to mediate cell signalling and to activate protective pathways, including that of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). In addition, HNE activates uncoupling proteins (UCPs), mitochondrial inner membrane proteins that mediate uncoupling of oxidative phosphorylation and have been proposed to protect against oxidative stress. It is not known, however, whether HNE might induce UCPs expression via Nrf2 to cause mitochondrial uncoupling. We invest...
Source: Free Radical Biology and Medicine - April 2, 2015 Category: Biology Authors: López-Bernardo E, Anedda A, Sánchez-Pérez P, Acosta-Iborra B, Cadenas S Tags: Free Radic Biol Med Source Type: research

Essential role of NRF2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.
In conclusion, our work has revealed that in hepatocytes, Nrf2 is an essential early player in the rescue of oxidative stress by LA leading to protection against PA-mediated lipoapoptosis. PMID: 25841776 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - April 1, 2015 Category: Biology Authors: Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, Módol T, Santamaría B, Weber M, Herrero L, Serra D, Muntané J, Cuadrado A, Moreno-Aliaga MJ, Alfredo Martínez J, Valverde ÁM Tags: Free Radic Biol Med Source Type: research

The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large cell lymphoma cell lines.
CONCLUSION: These results indicate that NOX5-derived ROS contributes to apoptosis blockage in ALK+ ALCL cell lines and suggest NOX5 as a potential pharmaceutical target to enhance apoptosis thus, to suppress tumor progression and prevent relapse in pediatric ALK+ ALCL patients that resist classical therapeutic approaches. PMID: 25797883 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 19, 2015 Category: Biology Authors: Carnesecchi S, Rougemont AL, Doroshow JH, Nagy M, Mouche S, Gumy-Pause F, Szanto I Tags: Free Radic Biol Med Source Type: research

Adiponectin Ameliorates Hyperglycemia-Induced Cardiac Hypertrophy and Dysfunction by Concomitantly Activating Nrf2 and Brg1.
Abstract Hyperglycemia-induced oxidative stress is implicated in the development of cardiomyopathy in diabetes that is associated with reduced adiponectin (APN) and heme oxygenase-1(HO-1). Brahma-related gene 1 (Brg1) assists nuclear factor-erythroid-2-related factor-2 (Nrf2) to activate HO-1 to increase myocardial antioxidant capacity in response to oxidative stress. We hypothesized that reduced adiponectin (APN) impairs HO-1 induction which contributes to the development of diabetic cardiomyopathy, and that supplementation of APN may ameliorate diabetic cardiomyopathy by activating HO-1 through Nrf2 and Brg1 in ...
Source: Free Radical Biology and Medicine - March 17, 2015 Category: Biology Authors: Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang L, Xia Z Tags: Free Radic Biol Med Source Type: research

Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition.
Abstract We previously reported the promising effect of dioscin against hepatic ischemia /reperfusion (I/R) injury, but its effect on cerebral I/R injury remains unknown. In this work, an in vitro oxygen-glucose deprivation and reoxygenation (OGD/R) model and an in vivo middle cerebral artery occlusion (MCAO) model were used. The results indicated that dioscin clearly protected PC12 cells and primary cortical neurons against OGD/R insult and significantly prevented cerebral I/R injury. Further research demonstrated that dioscin-induced neuroprotection was accompanied by a significant inhibition in the expression a...
Source: Free Radical Biology and Medicine - March 12, 2015 Category: Biology Authors: Tao X, Sun X, Yin L, Han X, Xu L, Qi Y, Xu Y, Li H, Lin Y, Liu K, Peng J Tags: Free Radic Biol Med Source Type: research