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DAP1 negatively regulates autophagy induced by cardamonin in SKOV3 cells.
This study aimed to investigate whether it is relevant for DAP1 in proliferation inhibition and autophagy induced by cardamonin in tumor cells. Using online bioinformatics tools, we found that DAP1 expression is closely related to the survival of patients with ovarian cancer. Our study showed that autophagy induced by cardamonin was associated with mTOR inhibition, and DAP1 was involved in this process. Silence of DAP1 decreased cell proliferation but enhanced antiproliferative effect of cardamonin in SKOV3 cells. The level of autophagy was elevated by DAP1 silencing in SKOV3 cells. Notably, cardamonin showed higher autoph...
Source: Cell Biology International - July 23, 2020 Category: Cytology Authors: Nie X, Chen H, Niu P, Zhu Y, Zhou J, Jiang L, Li D, Lin M, Chen Z, Shi D Tags: Cell Biol Int Source Type: research

OGR1 mediates the inhibitory effects of acidic environment on proliferation and angiogenesis of endothelial progenitor cells.
This study attempted to whether OGR1 mediates the effects of acid on proliferation, migration, and angiogenesis in EPCs. FITC-UEA-I and Dil-Ac-LDL double-staining methods were used to identify EPCs. Expression of OGR1 was analyzed by RT-PCR and western blot after incubation in media ranging in pH, cell counting kit-8 and cell cycle analysis were used to analyze proliferation and cell cycle distribution. Scratch test, transwell migration assay, and tube formation experiments were performed to analyze migration and vascularization of EPCs after silencing OGR1 with siRNA. The result show EPCs were positive for FITC-UEA-I and ...
Source: Cell Biology International - May 21, 2019 Category: Cytology Authors: Ding S, Xu J, Zhang Q, Chen F, Zhang J, Gui K, Xiong M, Li B, Ruan Z, Zhao M Tags: Cell Biol Int Source Type: research

TET1 promotes cisplatin-resistance via demethylating the vimentin promoter in ovarian cancer.
Abstract The development of chemo-resistance impairs the outcome of the first line platinum-based chemotherapies for ovarian cancer. Deregulation of DNA methylation/demethylation provides a critical mechanism for the occurrence of chemo-resistance. The ten-eleven translocation (TET) family of dioxygenases including TET1/2/3 plays an important part in DNA demethylation, but their roles in cisplatin resistance have not been elucidated. Using cisplatin-sensitive and cisplatin-resistant ovarian cancer cell models, we found that TET1 was significantly upregulated in cisplatin-resistant CP70 cells compared with that in ...
Source: Cell Biology International - February 1, 2017 Category: Cytology Authors: Han X, Zhou Y, You Y, Lu J, Wang L, Hou H, Li J, Chen W, Zhao L, Li X Tags: Cell Biol Int Source Type: research

Wnt5A exerts immunomodulatory activity in the human ovarian cancer cell line SKOV-3.
This study revealed a previously unrecognized immunomodulatory role of endogenous Wnt5A in ovarian cancer cells, which could further influence chemotactic cell migration. PMID: 26462870 [PubMed - as supplied by publisher]
Source: Cell Biology International - October 13, 2015 Category: Cytology Authors: Arabzadeh S, Hossein G, Zarnani AH Tags: Cell Biol Int Source Type: research

Fibronectin promotes migration and invasion of ovarian cancer cells through up-regulation of FAK-PI3K/Akt pathway.
This study investigates the mechanism of fibronectin (Fn) in stimulating ovarian cancer cell migration and invasion through up-regulation of FAK pathway. Human ovarian cancer cells (OVCAR-3, A2780/CP70) were cultured and treated with fibronectin (10 µg/ml). Trans-well plates were used to conduct the migration assay, real-time RT-PCR for FAK mRNA expression, and FAK siRNA for blocking FAK expression. Western blots were used for P-FAK, P-PI3K and P-Akt analysis. Fibronectin treated OVCAR-3, A2780/CP70 cells have increased ability to migrate and invade. It significantly promoted this behaviour through the phosphorylation o...
Source: Cell Biology International - September 21, 2013 Category: Cytology Authors: Yousif NG Tags: Cell Biol Int Source Type: research