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Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice
Biomed Pharmacother. 2022 Nov 13;157:114005. doi: 10.1016/j.biopha.2022.114005. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common among lipid metabolism disorders. Autophagy plays an important role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active ingredients of Pueraria lobata, exert antioxidant and anti-inflammatory effects. Herein, we report the potential lipid-lowering and anti-inflammatory effects of Pueraria flavonoids on NAFLD induced by a high-fat diet. In vivo and in vitro experiments showed that Pueraria flavonoids reduced intracellular lipid deposition by...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 16, 2022 Category: Drugs & Pharmacology Authors: Chunbin Sun Jin Zhang Jiong Hou Menglin Hui Hualong Qi Tong Lei Xiaoshuang Zhang Luxi Zhao Hongwu Du Source Type: research

Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
CONCLUSION: LBP seems to exert a negative feedback on ERα-mediated estrogen action, impacting on genes involved in thermogenesis. The known decreased estrogen action and negative effects of metabolic endotoxemia may be targeted through LBP downregulation.PMID:35643066 | DOI:10.1016/j.biopha.2022.113156
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 1, 2022 Category: Drugs & Pharmacology Authors: Ferran Comas Ramon D íaz-Trelles Aleix Gavald à-Navarro Edward Milbank Nathalia Dragano Samantha Mor ón-Ros Rajesh Mukthavaram Jessica Latorre Francisco Ortega Maria Arnoriaga-Rodriguez N úria Oliveras-Cañellas Wifredo Ricart Priya P Karmali Kiyoshi Source Type: research

Anti-inflammatory and anti-fibrotic effects of modafinil in nonalcoholic liver disease
Biomed Pharmacother. 2021 Dec;144:112372. doi: 10.1016/j.biopha.2021.112372. Epub 2021 Oct 28.ABSTRACTSmall- and intermediate-conductance Ca2+-activated K+ channels, KCa2.3 and KCa3.1, are involved in cellular signaling processes associated with inflammation and fibrosis. KCa2.3 and KCa3.1 are upregulated by proinflammatory cytokines and profibrotic growth factors. Cyclic AMP, which downregulates KCa2.3 and KCa3.1, is elevated by modafinil in cells; accordingly, we investigated whether modafinil exerts anti-inflammatory and anti-fibrotic responses via KCa2.3- and KCa3.1-mediated pathways in high-fat diet (HFD)- or thioacet...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2021 Category: Drugs & Pharmacology Authors: Shinkyu Choi Ji Aee Kim Haiyan Li Seong-Eun Jo Huisu Lee Tae Hun Kim Minje Kim Seong-Jin Kim Suk Hyo Suh Source Type: research

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway.
CONCLUSIONS: TMAO promotes the atherosclerosis in vivo and in vitro.CD36/MAPK/JNK pathway may play a crucial role in TMAO-induced formation of foam cells. PMID: 29136772 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 7, 2017 Category: Drugs & Pharmacology Authors: Geng J, Yang C, Wang B, Zhang X, Hu T, Gu Y, Li J Tags: Biomed Pharmacother Source Type: research