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Inhibition of CSF1R and AKT by ( ±)-kusunokinin hinders breast cancer cell proliferation.
Inhibition of CSF1R and AKT by (±)-kusunokinin hinders breast cancer cell proliferation. Biomed Pharmacother. 2020 Jun 11;129:110361 Authors: Rattanaburee T, Tipmanee V, Tedasen A, Thongpanchang T, Graidist P Abstract Kusunokinin, a lignan compound, inhibits cancer cell proliferation and induces apoptosis; however, the role of kusunokinin is not fully understood. Here, we aimed to identify a target protein of (-)-kusunokinin and determine the protein levels of its downstream molecules. We found that (-)-kusunokinin bound 5 possible target proteins, including CSF1R, MMP-12, HSP90-α, CyclinB1 and MEK1...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2020 Category: Drugs & Pharmacology Authors: Rattanaburee T, Tipmanee V, Tedasen A, Thongpanchang T, Graidist P Tags: Biomed Pharmacother Source Type: research

β-Glucosidase inhibition sensitizes breast cancer to chemotherapy.
Abstract The resistance to therapy is a major clinical challenge for advanced stage breast cancer. Identification of novel potential therapeutic targets is needed to overcome chemoresistance. In this work, we identified a target that was critically involved in breast cancer growth and chemoresistance. We demonstrated that β-glucosidase expression and activity were significantly upregulated in breast cancer tissues and a panel of cell lines compared to normal adjacent breast tissues and cell lines. β-glucosidase overexpression activated PI3K/Akt/mTOR signalling, leading to increased cell growth. In contrast, β-g...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2017 Category: Drugs & Pharmacology Authors: Zhou X, Huang Z, Yang H, Jiang Y, Wei W, Li Q, Mo Q, Liu J Tags: Biomed Pharmacother Source Type: research

HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway.
In conclusion, our results proved that HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway. PMID: 28407576 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2017 Category: Drugs & Pharmacology Authors: Yu Y, Lv F, Liang D, Yang Q, Zhang B, Lin H, Wang X, Qian G, Xu J, You W Tags: Biomed Pharmacother Source Type: research

Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line.
CONCLUSION: Our results suggest that the bach1 can be considered as a potent adjuvant in breast cancer therapy. PMID: 28092843 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 12, 2017 Category: Drugs & Pharmacology Authors: Aletaha M, Mansoori B, Mohammadi A, Fazeli M, Baradaran B Tags: Biomed Pharmacother Source Type: research

PGC-1 alpha interacts with microRNA-217 to functionally regulate breast cancer cell proliferation.
CONCLUSION: MiR-217 is the upstream regulator of PGC-1α in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway. PMID: 27916422 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2016 Category: Drugs & Pharmacology Authors: Zhang S, Liu X, Liu J, Guo H, Xu H, Zhang G Tags: Biomed Pharmacother Source Type: research

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
CONCLUSION: Our results indicated that BACH1 down-regulation in HT29 CRC cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression. Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment. PMID: 27657827 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2016 Category: Drugs & Pharmacology Authors: Davudian S, Shajari N, Kazemi T, Mansoori B, Salehi S, Mohammadi A, Shanehbandi D, Shahgoli VK, Asadi M, Baradaran B Tags: Biomed Pharmacother Source Type: research

Smoothened activates breast cancer stem-like cell and promotes tumorigenesis and metastasis of breast cancer.
Abstract Smoothened (Smo) is a G protein-coupled receptor protein encoded by the Smo gene of the hedgehog signalling pathway, which is thought to play an important role in maintaining organ patterning, cell differentiation and self-renewal. The possible role of Smo in the process of tumorigenesis and metastasis of breast cancer still remains unclear. The present experiments were to investigate the effect of Smo on activating breast cancer stem-like CD44(+)CD24(-) cells and the tumorigenesis and metastasis of breast cancer. By injected CD44(+)CD24(-) cells (1×10(4)) into the cleared fat pad of NOD/SCID mice, it wa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2014 Category: Drugs & Pharmacology Authors: Wang L, Duan W, Kang L, Mao J, Yu X, Fan S, Li L, Tao Y Tags: Biomed Pharmacother Source Type: research