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Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis
Biochim Biophys Acta Mol Basis Dis. 2023 Jan 10:166639. doi: 10.1016/j.bbadis.2023.166639. Online ahead of print.ABSTRACTEpiberberine (EPI), extracted from Rhizome Coptidis, has been shown to attenuate hyperlipidemia in vivo. Herein we have studied the mechanism by which EPI is active against non-alcoholic steatohepatitis (NASH) using, mice fed on a methionine- and choline-deficient (MCD) diet and HepG2 cells exposed to free fatty acids (FFA). We show that small heterodimer partner (SHP) protein is key in the regulation of lipid synthesis. In HepG2 cells and in the livers of MCD-fed mice, EPI elevated SHP levels, and this ...
Source: Biochimica et Biophysica Acta - January 13, 2023 Category: Biochemistry Authors: Li-Ming Zhou Jin-Hua Fan Min-Min Xu Meng-Yuan Xiong Qiao-Jiao Wang Xue Chai Xiao-Duo Li Xue-Gang Li Xiao-Li Ye Source Type: research

Therapeutic DNA vaccine encoding CEMIP (KIAA1199) ameliorates kidney fibrosis in obesity through inhibiting the Wnt/ β-catenin pathway
CONCLUSION: DNA vaccine targeting CEMIP/Wnt1/β-catenin pathway plays a novel strategy in nephropathy.GENERAL SIGNIFICANCE: Immune therapy might provide a new therapeutic option on nephropathy of obesity.PMID:34582938 | DOI:10.1016/j.bbagen.2021.130019
Source: Biochimica et Biophysica Acta - September 28, 2021 Category: Biochemistry Authors: Chao-Hung Chen Guan-Ming Ke Pi-Chen Lin Kun-Der Lin Source Type: research

ERK5/KLF2 activation is involved in the reducing effects of puerarin on monocyte adhesion to endothelial cells and atherosclerotic lesion in apolipoprotein E-deficient mice.
Abstract Puerarin has properties of anti-oxidation and anti-inflammation, which has been demonstrated protective effects in atherosclerosis and other cardiovascular diseases. However, the detail molecular mechanism still remains unclear. Here, we determined whether the atheroprotective effect of puerarin was by reducing monocyte adhesion and explored the underlying mechanism. The results showed that puerarin dose- and time-dependently reduced oxLDL-induced monocyte THP-1 adhesion to HUVECs and the expression of adhesion-related genes such as VCAM-1, ICAM-1, MCP-1 and IL-8 in HUVECs. Puerarin activated ERK5 phospho...
Source: Biochimica et Biophysica Acta - April 30, 2018 Category: Biochemistry Authors: Deng Y, Lei T, Li H, Mo X, Wang Z, Ou H Tags: Biochim Biophys Acta Source Type: research