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Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2
Biochim Biophys Acta Mol Cell Res. 2023 Mar 18:119466. doi: 10.1016/j.bbamcr.2023.119466. Online ahead of print.ABSTRACTDistorted neuronal calcium signaling has been reported in many neurodegenerative disorders, including different types of spinocerebellar ataxias (SCAs). Cerebellar Purkinje cells (PCs) are primarily affected in SCAs and the disturbances in the calcium homeostasis were observed in SCA PCs. Our previous results have revealed that 3,5-dihydroxyphenylglycine (DHPG) induced greater calcium responses in SCA2-58Q PC cultures than in wild type (WT) PC cultures. Here we observed that glutamate-induced calcium rele...
Source: Biochimica et Biophysica Acta - March 20, 2023 Category: Biochemistry Authors: Polina A Egorova Ksenia S Marinina Ilya B Bezprozvanny Source Type: research

Short interfering RNA delivered by a hybrid nanoparticl ße targeting VEGF: Biodistribution and anti-tumor effect
CONCLUSION: The hybrid system prepared was successful in promoting the RNAi effect in vivo with very low toxicity.GENERAL SIGNIFICANCE: This study shows the valuable development of a hybrid nanoparticle carrying VEGF siRNA, as well as their tumor targeting, accumulation and reduction in mice triple-negative breast cancer.PMID:34062235 | DOI:10.1016/j.bbagen.2021.129938
Source: Biochimica et Biophysica Acta - June 1, 2021 Category: Biochemistry Authors: Gabriela Regina Rosa Souza Milene Dalmina Jelver Alexander Sierra Restrepo Le ônidas João de Mello Junior Adny Henrique Silva Ana Gualberto Jacy Gameiro Dalton Dittz Andr é Avelino Pasa Frederico Pittella T ânia Beatriz Creczynski-Pasa Source Type: research