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Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension
CONCLUSIONS: Iron deficiency promoted oxidative stress and apoptosis in HPAECs in hypoxia-induced PH, and enhanced expression of hepcidin regulated by BMP6/BMPR2 signaling may contribute to iron metabolic disorder.PMID:36343841 | DOI:10.1016/j.bbadis.2022.166589
Source: Biochimica et Biophysica Acta - November 7, 2022 Category: Biochemistry Authors: Yujie Jiang Yingfan Guo Xuexiang Feng Pingting Yang Yi Liu Xuejing Dai Feilong Zhao Dongyu Lei Xiaohui Li Yuan Liu Ying Li Source Type: research

Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production
Biochim Biophys Acta Mol Basis Dis. 2021 Aug 26:166261. doi: 10.1016/j.bbadis.2021.166261. Online ahead of print.ABSTRACTRapamycin insensitive companion of mechanistic target of Rapamycin (Rictor), the key component of mTOR complex 2 (mTORC2), controls both β-cell proliferation and function. We sought to study whether long chain acyl-CoA synthetase 4 (Acsl4) worked downstream of Rictor/mTORC2 to maintain β-cell functional mass. We found Acsl4 was positively regulated by Rictor at transcriptional and posttranslational levels in mouse β-cell. Infecting adenovirus expressing Acsl4 in β-cell-specific-Rictor-knockout (βRic...
Source: Biochimica et Biophysica Acta - August 29, 2021 Category: Biochemistry Authors: Canqi Cui Tingting Li Yun Xie Jie Yang Chenyang Fu Yixuan Qiu Linyan Shen Qicheng Ni Qidi Wang Aifang Nie Guang Ning Weiqing Wang Yanyun Gu Source Type: research