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Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells
Biochim Biophys Acta Mol Cell Res. 2023 Jun 12:119522. doi: 10.1016/j.bbamcr.2023.119522. Online ahead of print.ABSTRACTProstate cancer (PCa) continues to be one of the most common cancers in men worldwide. The six transmembrane epithelial antigen of the prostate 1 (STEAP1) protein is overexpressed in several types of human tumors, particularly in PCa. Our research group has demonstrated that STEAP1 overexpression is associated with PCa progression and aggressiveness. Therefore, understanding the cellular and molecular mechanisms triggered by STEAP1 overexpression will provide important insights to delineate new strategies...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Sandra M Rocha F átima M Santos S ílvia Socorro Lu ís A Passarinha Cl áudio J Maia Source Type: research

P21 Activated Kinase-1 Mediates Transforming Growth Factor β1-Induced Prostate Cancer Cell Epithelial to Mesenchymal Transition.
Abstract Transforming growth factor beta (TGFβ) is believed to play a dual role in prostate cancer. Molecular mechanism by which TGFβ1 suppresses early prostate tumor growth and induces epithelial-to-mesenchymal transition (EMT) in advanced stages is not known. We determined if P21-activated kinase1 (Pak1), which mediates cytoskeletal remodeling is necessary for the TGFβ1 induced prostate cancer EMT. Effects of TGFβ1 on control prostate cancer PC3 and DU145 cells and those with IPA 3 and siRNA mediated Pak1 inhibition were tested for prostate tumor xenograft in vivo and EMT in vitro. TGFβ1 inhibited PC3 tumor...
Source: Biochimica et Biophysica Acta - March 5, 2015 Category: Biochemistry Authors: Al-Azayzih A, Gao F, Somanath PR Tags: Biochim Biophys Acta Source Type: research