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Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells
Biochim Biophys Acta Mol Cell Res. 2023 Jun 12:119522. doi: 10.1016/j.bbamcr.2023.119522. Online ahead of print.ABSTRACTProstate cancer (PCa) continues to be one of the most common cancers in men worldwide. The six transmembrane epithelial antigen of the prostate 1 (STEAP1) protein is overexpressed in several types of human tumors, particularly in PCa. Our research group has demonstrated that STEAP1 overexpression is associated with PCa progression and aggressiveness. Therefore, understanding the cellular and molecular mechanisms triggered by STEAP1 overexpression will provide important insights to delineate new strategies...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Sandra M Rocha F átima M Santos S ílvia Socorro Lu ís A Passarinha Cl áudio J Maia Source Type: research

Autophagy regulates transforming growth factor β signaling and receptor trafficking
Biochim Biophys Acta Mol Cell Res. 2022 May 20:119284. doi: 10.1016/j.bbamcr.2022.119284. Online ahead of print.ABSTRACTTransforming growth factor beta (TGFβ) stimulates tumorigenesis by inducing epithelial to mesenchymal transition (EMT) and cell migration. TGFβ signaling is regulated by the endocytosis of cell surface receptors and their subcellular trafficking into the endo-lysosomal system. Here we investigated how autophagy, a cellular quality control network that delivers material to lysosomes, regulates TGFβ signaling pathways that induce EMT and cell migration. We impaired autophagy in non-small cell lung cancer...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: Charles B Trelford Gianni M Di Guglielmo Source Type: research

Therapeutic DNA vaccine encoding CEMIP (KIAA1199) ameliorates kidney fibrosis in obesity through inhibiting the Wnt/ β-catenin pathway
CONCLUSION: DNA vaccine targeting CEMIP/Wnt1/β-catenin pathway plays a novel strategy in nephropathy.GENERAL SIGNIFICANCE: Immune therapy might provide a new therapeutic option on nephropathy of obesity.PMID:34582938 | DOI:10.1016/j.bbagen.2021.130019
Source: Biochimica et Biophysica Acta - September 28, 2021 Category: Biochemistry Authors: Chao-Hung Chen Guan-Ming Ke Pi-Chen Lin Kun-Der Lin Source Type: research

P21 Activated Kinase-1 Mediates Transforming Growth Factor β1-Induced Prostate Cancer Cell Epithelial to Mesenchymal Transition.
Abstract Transforming growth factor beta (TGFβ) is believed to play a dual role in prostate cancer. Molecular mechanism by which TGFβ1 suppresses early prostate tumor growth and induces epithelial-to-mesenchymal transition (EMT) in advanced stages is not known. We determined if P21-activated kinase1 (Pak1), which mediates cytoskeletal remodeling is necessary for the TGFβ1 induced prostate cancer EMT. Effects of TGFβ1 on control prostate cancer PC3 and DU145 cells and those with IPA 3 and siRNA mediated Pak1 inhibition were tested for prostate tumor xenograft in vivo and EMT in vitro. TGFβ1 inhibited PC3 tumor...
Source: Biochimica et Biophysica Acta - March 5, 2015 Category: Biochemistry Authors: Al-Azayzih A, Gao F, Somanath PR Tags: Biochim Biophys Acta Source Type: research