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RNA Silencing: a Model to Explore the MRGPRX2-pathway in Cultured Human Mast Cells.
MRGPRX2 is a G-protein-coupled receptor that is expressed on human mast cells (hMC). Substance P MRGPRX2-pathway is a recent described IgE-independent activation route, such as off-target occupation through drugs. Unfortunately, there are no specific MRGPRX2 inhibitors allowing to deepen our insights in the MRGPRX2-activation pathway(s). Therefore, the aim of this study is to explore whether MRGPRX2-expression can be silenced via siRNA technology.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Jessy Elst, Vito Sabato, Margaretha Faber, Christel Mertens, Margo Hagendorens, Luc De Clerck, Diana Campillo-Davo, Viggo Van Tendeloo, Didier Ebo Source Type: research

A novel allergen-specific therapy with CD40-silenced B cells and dendritic cells
CD40-silenced B cells, induced by siRNA, inhibited allergic responses and symptoms antigen-specifically even after allergic rhinitis had been established. CD40-silenced B cells and CD40-silenced dendritic cells also have independent mechanisms with a synergic effect.
Source: Journal of Allergy and Clinical Immunology - August 22, 2018 Category: Allergy & Immunology Authors: Motohiko Suzuki, Makoto Yokota, Yoshihisa Nakamura, Shinya Ozaki, Shingo Murakami Source Type: research

A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders
Conclusions: Our results identified a new nucleic acid–based agent (CD8 aptamer–GNLY siRNA chimera) that can significantly inhibit CTL-mediated drug hypersensitivity, such as that seen in patients with SJS/TEN, as well as the alloreactivity seen in patients with GVHD. This study provides a novel therapeutic strategy for CTL-mediated immune disorders.
Source: Journal of Allergy and Clinical Immunology - June 21, 2013 Category: Allergy & Immunology Authors: Chuang-Wei Wang, Wen-Hung Chung, Yi-Fang Cheng, Nien-Wen Ying, Konan Peck, Yuan-Tsong Chen, Shuen-Iu Hung Tags: Mechanisms of allergy and clinical immunology Source Type: research

Herpesviruses and the microbiome
The focus of this article will be to examine the role of common herpesviruses as a component of the microbiome of atopic patients and to review clinical observations suggesting that atopic patients might be predisposed to more severe and atypical herpes-related illness because their immune response is biased toward a TH2 cytokine profile. Human populations are infected with 8 herpesviruses, including herpes simplex virus HSV1 and HSV2 (also termed HHV1 and HHV2), varicella zoster virus (VZV or HHV3), EBV (HHV4), cytomegalovirus (HHV5), HHV6, HHV7, and Kaposi sarcoma–associated herpesvirus (termed KSV or HHV8). Herpesviru...
Source: Journal of Allergy and Clinical Immunology - April 22, 2013 Category: Allergy & Immunology Authors: David H. Dreyfus Tags: Rostrum Source Type: research

AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice
Conclusions: The Fyn-regulated LKB1-AMPK axis acts as a novel inhibitory module for mast cell activation, which points to AMPK activators as therapeutic drugs for allergic diseases.
Source: Journal of Allergy and Clinical Immunology - April 15, 2013 Category: Allergy & Immunology Authors: Seung-Lark Hwang, Xian Li, Yue Lu, Ye Jin, Yong-Tae Jeong, Yong Deuk Kim, In-Kyu Lee, Yoshitaka Taketomi, Hiroyasu Sato, You Sook Cho, Makoto Murakami, Hyeun Wook Chang Tags: Mechanisms of allergy and clinical immunology Source Type: research