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Source: Journal of Cellular Physiology

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Total 116 results found since Jan 2013.

Acetylcholine Inhibits Tumor Necrosis Factor α Activated Endoplasmic Reticulum Apoptotic Pathway via EGFR‐PI3K Signaling in Cardiomyocytes
This study was aimed at determining the effect of ACh in H9c2 cells after TNF α stimulation. Presence of ER stress was verified using the ER stress protein markers glucose regulatory protein 78 (GRP78) and C/EBP homologous protein (CHOP). Cell apoptosis was shown by caspase‐3 activation and terminal deoxynucleotidyl transferase mediated dUTP‐biotin nick end labeling. Exogenously administered ACh significantly decreased these TNF α‐induced changes. Moreover, when the cells were exposed to nonspecific muscarinic receptor (M AChR) inhibitor atropine, methoctramine (M2 AChR inhibitor) or the epidermal growth factor rec...
Source: Journal of Cellular Physiology - September 9, 2014 Category: Cytology Authors: Yi Miao, Xue‐Yuan Bi, Mei Zhao, Hong‐Ke Jiang, Jin‐Jun Liu, Dong‐Ling Li, Xiao‐Jiang Yu, Yong‐Hua Yang, Ning Huang, Wei‐Jin Zang Tags: Original Research Article Source Type: research

The GPER agonist G‐1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER
The G protein‐coupled estrogen receptor (GPER) has been implicated in the regulation of smooth muscle cell (SMC) proliferation. The GPER selective agonist G‐1 has been a useful tool for exploring the biological roles of GPER in a variety of experimental settings, including SMC proliferation. The present study, originally designed to investigate cellular and signaling mechanisms underlying the regulatory role of GPER in vascular SMC proliferation using G‐1, unexpectedly revealed off‐target effects of G‐1. G‐1 (1‐10 μM) inhibited bromodeoxyuridine (BrdU) incorporation of human SMCs and caused G2/M cell accumul...
Source: Journal of Cellular Physiology - September 10, 2014 Category: Cytology Authors: Yu Gui, Zhan Shi, Zeng Yong Wang, Jing‐Jing Li, Can Xu, Rui Juan Tian, Xin Xing Song, Michael P. Walsh, Dong Li, Jie Gao, Xi‐Long Zheng Tags: Original Research Article Source Type: research

UCP2‐related mitochondrial pathway participates in oroxylin A‐induced apoptosis in human colon cancer cells
In conclusion, we have demonstrate that UCP2 play a key role in mitochondrial apoptotic pathway; UCP2's inhibition by oroxylin A triggers the MPTP opening, and promotes the apoptosis in CaCo‐2 cells. J. Cell. Physiol. © 2014 Wiley Periodicals, Inc.
Source: Journal of Cellular Physiology - September 24, 2014 Category: Cytology Authors: Chen Qiao, Libin Wei, Qinsheng Dai, Yuxin Zhou, Qian Yin, Zhiyu Li, Yuanming Xiao, Qinglong Guo, Na Lu Tags: Original Research Article Source Type: research

CCN1 Secreted by Tonsil‐Derived Mesenchymal Stem Cells Promotes Endothelial Cell Angiogenesis via Integrin αvβ3 and AMPK
Abstract CCN1 is highly expressed in cancer cells and has been identified in the secretome of bone marrow‐derived mesenchymal stem cells (BM‐MSC). Although secreted CCN1 is known to promote angiogenesis, its underlying mechanism remains unclear. Here, we examined whether our recently‐established tonsil‐derived MSC (T‐MSC) secrete CCN1 and, if any, how CCN1 promotes the angiogenesis of human umbilical vein endothelial cells (HUVEC). Compared with untreated control T‐MSC, a higher level of CCN1 was secreted by T‐MSC treated with activin A and sonic hedgehog, drugs known to induce endodermal differentiation. Exp...
Source: Journal of Cellular Physiology - September 29, 2014 Category: Cytology Authors: Yoon Shin Park, Soojin Hwang, Yoon Mi Jin, Yeonsil Yu, Sung‐Ae Jung, Sung‐Chul Jung, Kyung‐Ha Ryu, Han Su Kim, Inho Jo Tags: Original Research Article Source Type: research

DNA‐PKcs deficiency inhibits glioblastoma cell‐derived angiogenesis after ionizing radiation
DNA‐dependent protein kinase catalytic subunit (DNA‐PKcs) plays a critical role in non‐homologous end‐joining repair of DNA double‐strand breaks (DSB) induced by ionizing radiation (IR). Little is known, however, regarding the relationship between DNA‐PKcs and IR‐induced angiogenesis; thus, in this study we aimed to further elucidate this relationship. Our findings revealed that lack of DNA‐PKcs expression or activity sensitized glioma cells to radiation due to the defective DNA DSB repairs and inhibition of phosphorylated AktSer473. Moreover, DNA‐PKcs deficiency apparently mitigated IR‐induced migratio...
Source: Journal of Cellular Physiology - October 7, 2014 Category: Cytology Authors: Yang Liu, Luwei Zhang, Yuanyuan Liu, Chao sun, Hong Zhang, Guoying Miao, Cui Xiao Di, Xin Zhou, Rong Zhou, Zhenhua Wang Tags: Original Research Article Source Type: research

Galectin‐1 triggers epithelial‐mesenchymal transition in human hepatocellular carcinoma cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 5, 2014 Category: Cytology Authors: María L Bacigalupo, Malena Manzi, María V Espelt, Lucas D Gentilini, Daniel Compagno, Diego J Laderach, Carlota Wolfenstein‐Todel, Gabriel A Rabinovich, María F Troncoso Tags: Original Research Article Source Type: research

Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in nonsmall cell lung cancer (NSCLC) cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 11, 2014 Category: Cytology Authors: Anna Sobol, Paola Galluzzo, Megan J. Weber, Sara Alani, Maurizio Bocchetta Tags: Original Research Article Source Type: research

Phospholipase C epsilon‐induced TRPC6 activation: A common but redundant mechanism in primary podocytes
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 18, 2014 Category: Cytology Authors: Hermann Kalwa, Ursula Storch, Jana Demleitner, Susanne Fiedler, Tim Mayer, Martina Kannler, Meike Fahlbusch, Holger Barth, Alan Smrcka, Friedhelm Hildebrandt, Thomas Gudermann, Alexander Dietrich Tags: Original Research Article Source Type: research

Wild‐type and Specific Mutant Androgen Receptor Mediates Transcription via 17β‐Estradiol in Sex Hormone‐sensitive Cancer Cells
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Source: Journal of Cellular Physiology - December 23, 2014 Category: Cytology Authors: Takao Susa, Reina Ikaga, Takashi Kajitani, Masayoshi Iizuka, Hiroko Okinaga, Mimi Tamamori‐Adachi, Tomoki Okazaki Tags: Original Research Article Source Type: research

Chemokine (C‐C motif) ligand 5 is involved in tumor‐associated dendritic cell‐mediated colon cancer progression through non‐coding RNA MALAT‐1
In conclusion, the inhibition of CCL5 or CCL5‐related signaling may be an attractive therapeutic target in colon cancer patients. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 24, 2014 Category: Cytology Authors: Jung‐Yu Kan, Deng‐Chyang Wu, Fang‐Jung Yu, Cheng‐Ying Wu, Ya‐Wen Ho, Yen‐Jung Chiu, Shu‐Fang Jian, Jen‐Yu Hung, Jaw‐Yuan Wang, Po‐Lin Kuo Tags: Original Research Article Source Type: research

Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients
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Source: Journal of Cellular Physiology - December 29, 2014 Category: Cytology Authors: Kristin Friebel, Roland Schönherr, Raimund W. Kinne, Elke Kunisch Tags: Original Research Article Source Type: research

Shear Stress Modulates Resistin‐Induced CC Chemokine Ligand 19 Expression in Human Aortic Endothelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - February 5, 2015 Category: Cytology Authors: Hong‐Ren Yu, Mao‐Ling Sung, Hsing‐Chun Kuo, Chi‐Hui Lin, Cheng‐Nan Chen Tags: Original Research Article Source Type: research

­­Depletion of Amyloid Precursor Protein (APP) Causes G0 Arrest in Non‐Small Cell Lung Cancer (NSCLC) Cells
We recently reported that Amyloid Precursor Protein (APP) regulates global protein synthesis in a variety of human dividing cells, including non‐small cell lung cancer (NSCLC) cells. More specifically, APP depletion causes an increase of both cap‐ and IRES‐dependent translation. Since growth and proliferation are tightly coupled processes, here, we asked what effects artificial downregulation of APP could have elicited in NSCLC cells proliferation. APP depletion caused a G0/G1 arrest through destabilization of the cyclin‐C protein and reduced pRb phosphorylation at residues Ser802/811. siRNA to cyclin‐C mirrored ...
Source: Journal of Cellular Physiology - February 25, 2015 Category: Cytology Authors: Anna Sobol, Paola Galluzzo, Megan J. Weber, Sara Alani, Maurizio Bocchetta Tags: Original Research Article Source Type: research

Phospholipase C Epsilon (PLCε) Induced TRPC6 Activation: A Common but Redundant Mechanism in Primary Podocytes
In eukaryotic cells, activation of phospholipase C (PLC)‐coupled membrane receptors by hormones leads to an increase in the intracellular Ca2+ concentration [Ca2+]i. Catalytic activity of PLCs results in the hydrolysis of phosphatidylinositol 4,5‐bisphosphate to generate inositol 1,4,5‐trisphosphate (IP3) and diacylglycerol (DAG) which opens DAG‐sensitive classical transient receptor channels 3, 6, and 7 (TRPC3/6/7), initiating Ca2+ influx from the extracellular space. Patients with focal segmental glomerulosclerosis (FSGS) express gain‐of‐function mutants of TRPC6, while others carry loss‐of‐function mutan...
Source: Journal of Cellular Physiology - February 25, 2015 Category: Cytology Authors: Hermann Kalwa, Ursula Storch, Jana Demleitner, Susanne Fiedler, Tim Mayer, Martina Kannler, Meike Fahlbusch, Holger Barth, Alan Smrcka, Friedhelm Hildebrandt, Thomas Gudermann, Alexander Dietrich Tags: Original Research Article Source Type: research

Gap Junctions Enhance the Antiproliferative Effect of MicroRNA‐124‐3p in Glioblastoma Cells
In conclusion, our results indicate that the “bystander” effects of functional gap junctions composed of connexin 43 enhance the antitumor effect of miR‐124‐3p in glioblastoma cells by transferring miR‐124‐3p to adjacent cells, thereby enhancing G0/G1 cell cycle arrest. These observations provide a new guiding strategy for the clinical application of miRNA therapy in tumor treatment. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - March 9, 2015 Category: Cytology Authors: Suzhi Zhang, Qin Wang, Lucy Liu, Xiaoting Hong, Yuan Zhang, Liang Tao Tags: Original Research Article Source Type: research