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Source: Journal of Cellular Physiology

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Total 116 results found since Jan 2013.

CD44 Influences Fibroblast Behaviors Via Modulation of Cell–Cell and Cell–Matrix Interactions, Affecting Survivin and Hippo Pathways
CD44 has been studied in a wide variety of cell types, in a diverse array of cell behaviors and in a diverse range of signaling pathways. We now document a role for CD44 in mediating fibroblast behaviors via regulation of N‐cadherin, extracellular matrix expression, Survivin and the Hippo pathway. Here, we report our findings on the roles of CD44 in modulating proliferation, apoptosis, migration and invasion of murine wild‐type (WT‐FB) and CD44 knockout dermal fibroblasts (CD44KO‐FB). As we have documented in microvascular endothelial cells lacking CD44, we found persistent increased proliferation, reduced activati...
Source: Journal of Cellular Physiology - November 23, 2015 Category: Cytology Authors: Masayuki Tsuneki, Joseph A. Madri Tags: Original Research Article Source Type: research

Runx2/DICER/miRNA Pathway in Regulating Osteogenesis
In conclusion, our results suggest that DICER is specifically regulated by osteogenic master gene Runx2 that binds to the DICER promoter. Consequently, DICER cleaves precursors of miR‐335‐5p and miR‐17‐92 cluster to form mature miRNAs, which target and decrease the Dickkopf‐related protein 1 (DKK1) and proapoptotic factor BIM levels, respectively, leading to an enhanced Wnt/β‐catenin signaling pathway. These intriguing results reveal a central mechanism underlying lineage‐specific regulation by a Runx2/DICER/miRNAs cascade during osteogenic differentiation and bone development. Our study also suggests a pote...
Source: Journal of Cellular Physiology - April 11, 2016 Category: Cytology Authors: Leilei Zheng, Qisheng Tu, Shu Meng, Lan Zhang, Liming Yu, Jinlin Song, Yun Hu, Lei Sui, Jin Zhang, Michel Dard, Jessica Cheng, Dana Murray, Jane Lian, Gary Stein, Jake Chen Tags: Original Research Article Source Type: research

Hypoxia ‐induced apoptosis of mouse spermatocytes is mediated by HIF‐1α through a death receptor pathway and a mitochondrial pathway
In conclusion, our data suggest that the death receptor pathway and mitochondrial pathway, which are likely mediated by HIF‐1α, contribute to hypoxia‐induced GC‐2 cell apoptosis. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - April 26, 2017 Category: Cytology Authors: Jun Yin, Bing Ni, Wei ‐gong Liao, Yu‐qi Gao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Ptn functions downstream of C/EBP β to mediate the effects of cAMP on uterine stromal cell differentiation through targeting Hand2 in response to progesterone
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - June 28, 2017 Category: Cytology Authors: Hai ‐Fan Yu, Ran Tao, Zhan‐Qing Yang, Kai Wang, Zhan‐Peng Yue, Bin Guo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Wnt5a Suppresses Osteoblastic Differentiation of Human Periodontal Ligament Stem Cell ‐like Cells Via Ror2/JNK signaling
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - July 6, 2017 Category: Cytology Authors: Daigaku Hasegawa, Naohisa Wada, Shinichiro Yoshida, Hiromi Mitarai, Mai Arima, Atsushi Tomokiyo, Sayuri Hamano, Hideki Sugii, Hidefumi Maeda Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The MIP ‐1α autocrine loop contributes to decreased sensitivity to anticancer drugs
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - October 23, 2017 Category: Cytology Authors: Masanobu Tsubaki, Tomoya Takeda, Yoshika Tomonari, Kenji Mashimo, Yu ‐ichi Koumoto, Sachi Hoshida, Tatsuki Itoh, Motohiro Imano, Takao Satou, Katsuhiko Sakaguchi, Shozo Nishida Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Activation and promotion of adipose tissue‐derived mesenchymal stem cells by tumour necrosis factor‐alpha preconditioning for bone tissue engineering
This study investigated the effect of short‐term (three days) preconditioning with tumour necrosis factor‐alpha (TNF‐α) on proliferation, mobilization and differentiation of adipose tissue‐derived mesenchymal stem cells (ASCs). We demonstrated that TNF‐α pre‐conditioning increased proliferation, mobilization, and osteogenic differentiation of ASCs and up‐regulated bone morphogenetic protein‐2 (BMP‐2) protein levels. BMP‐2 silencing by siRNA partially inhibited osteogenic differentiation of ASCs induced by TNF‐α; BMP‐2 pre‐conditioning also significantly increased osteogenic differentiation of A...
Source: Journal of Cellular Physiology - January 28, 2013 Category: Cytology Authors: ZuFu Lu, GuoCheng Wang, Colin R Dunstan, YongJun Chen, William Yenn‐Ru Lu, Ben Davies, Hala Zreiqat Tags: Original Research Article Source Type: research

Omega‐3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF‐7 breast cancer cells
Abstract The omega‐3 long chain polyunsaturated fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), elicit anti‐proliferative effects in cancer cell lines and in animal models. Dietary DHA and EPA can be converted to their ethanolamide derivatives, docosahexaenoyl ethanolamine (DHEA), and eicosapentaenoyl ethanolamine (EPEA), respectively; however, few studies are reported on their anti‐cancer activities. Here, we demonstrated that DHEA and EPEA were able to reduce cell viability in MCF‐7 breast cancer cells whereas they did not elicit any effects in MCF‐10A non‐tumorigenic breast epitheli...
Source: Journal of Cellular Physiology - February 25, 2013 Category: Cytology Authors: Daniela Rovito, Cinzia Giordano, Donatella Vizza, Pierluigi Plastina, Ines Barone, Ivan Casaburi, Marilena Lanzino, Francesca De Amicis, Diego Sisci, Loredana Mauro, Saveria Aquila, Stefania Catalano, Daniela Bonofiglio, Sebastiano Andò Tags: Original Research Article Source Type: research

MicroRNA‐195 chemosensitizes colon cancer cells to the chemotherapeutic drug doxorubicin by targeting the first binding site of BCL2L2 mRNA
In this study, we utilized microRNA array and real‐time PCR to verify that some microRNAs including miR‐127, miR‐195, miR‐22, miR‐137 were significantly down‐regulated, while miR‐21, miR‐592 were up‐regulated in both HT29/DOX and LOVO/DOX cell lines. In vitro cell viability assay showed that knockdown of miR‐195 in HT29 and LOVO cells caused a marked inhibition of Dox‐induced cytotoxicity. Moreover, we explored that miR‐195 is involved in repression of BCL2L2 expression through targeting its 3'‐untranslated region, especially the first binding site within its mRNA. Furthermore, down‐regulation o...
Source: Journal of Cellular Physiology - March 22, 2013 Category: Cytology Authors: Juan Qu, Liang Zhao, Pengzhi Zhang, Juan Wang, Ning Xu, Wenjuan Mi, Xingwang Jiang, Changming Zhang, Juan Qu Tags: Original Research Article Source Type: research

CCL20 induces migration and proliferation on breast epithelial cells
Abstract The communication between the tumour cells and the surrounding cells helps drive the process of tumour progression. Since the microenvironment of breast cancer includes CCL20 chemokine, the purpose of this study was to determine whether CCL20 modulates the physiology of healthy breast epithelial cells in areas adjacent to the tumour. Therefore, primary cultures of mammary cells taken from normal peritumoral areas were used. We assessed that breast cells expressed CCR6 CCL20 receptor. Using molecular (siRNA) and pharmacological (inhibitors) techniques we found multiple signalling kinases to be activated by CCR6 and...
Source: Journal of Cellular Physiology - March 4, 2013 Category: Cytology Authors: Santo Marsigliante, Carla Vetrugno, Antonella Muscella Tags: Original Research Article Source Type: research

Activation and promotion of adipose stem cells by tumour necrosis factor‐alpha preconditioning for bone regeneration
This study investigated the effect of short‐term (3 days) preconditioning with tumor necrosis factor‐alpha (TNF‐α) on proliferation, mobilization, and differentiation of adipose tissue‐derived mesenchymal stem cells (ASCs). We demonstrated that TNF‐α pre‐conditioning increased proliferation, mobilization, and osteogenic differentiation of ASCs and up‐regulated bone morphogenetic protein‐2 (BMP‐2) protein level. BMP‐2 silencing by siRNA partially inhibited osteogenic differentiation of ASCs induced by TNF‐α; BMP‐2 pre‐conditioning also significantly increased osteogenic differentiation of ASCs b...
Source: Journal of Cellular Physiology - April 18, 2013 Category: Cytology Authors: ZuFu Lu, GuoCheng Wang, Colin R. Dunstan, YongJun Chen, William Yenn‐Ru Lu, Ben Davies, Hala Zreiqat Tags: Original Research Article Source Type: research

Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells
Abstract Hexokinase II (HK2), the enzyme that catalyzes the first committed step of glycolysis, is overexpressed in many cancers, as is the central signaling kinase Akt. Akt activity promotes HK2 association with the mitochondria, as well as glucose uptake by cancer cells. In HeLa cervical cancer cells, Akt inhibitor IV (Ai4) increased nuclear HK2 localization, while in MDA‐MB‐231 breast cancer cells, Ai4 merely induced cytoplasmic redistribution without increased nuclear accumulation. Small interfering RNA (siRNA) directed against Akt confirmed the effect in HeLa cells. Next, we treated the cells with clotrimazole (CT...
Source: Journal of Cellular Physiology - April 30, 2013 Category: Cytology Authors: Catherine L. Neary, John G. Pastorino Tags: Original Research Article Source Type: research

TRPM7 channels regulate proliferation and adipogenesis in 3T3‐L1 preadipocytes
Abstract Transient receptor potential melastatin‐7 (TRPM7) channels are involved in many cellular physiological and pathological processes. The present study was designed to investigate the expression of TRPM7 channels and the potential role in regulating cell proliferation and adipogenesis in 3T3‐L1 preadipocytes with approaches of whole‐cell patch voltage‐clamp, molecular biology, cell proliferation, adipogenesis, etc. We found that a TRPM7‐like current was recorded with Mg2+‐free pipette solution in 3T3‐L1 preadipocytes, and the current was inhibited by intercellular free Mg2+. The TRPM7‐like current was...
Source: Journal of Cellular Physiology - June 14, 2013 Category: Cytology Authors: Kui‐Hao Chen, Xiao‐Hui Xu, Yi Liu, Yan Hu, Man‐Wen Jin, Gui‐Rong Li Tags: Original Research Article Source Type: research

Testosterone increases GLUT4‐dependent glucose uptake in cardiomyocytes
Abstract Testosterone exerts important effects in the heart. Cardiomyocytes are target cells for androgens, and testosterone induces rapid effects via Ca2+ release and protein kinase activation and long‐term effects via cardiomyocyte differentiation and hypertrophy. Furthermore, it stimulates metabolic effects such as increasing glucose uptake in different tissues. Cardiomyocytes preferentially consume fatty acids for ATP production, but under particular circumstances, glucose uptake is increased to optimize energy production. We studied the effects of testosterone on glucose uptake in cardiomyocytes. We found that testo...
Source: Journal of Cellular Physiology - June 11, 2013 Category: Cytology Authors: Carlos Wilson, Ariel Contreras‐Ferrat, Nathaly Venegas, César Osorio‐Fuentealba, Mario Pávez, Katherine Montoya, Javier Durán, Rodrigo Maass, Sergio Lavandero, Manuel Estrada Tags: Original Research Article Source Type: research

Regulation of cellular processes by interleukin‐16 in homeostasis and cancer
This article will review the cellular process for generating IL‐16, the biological activities for both the pro‐ and secreted forms of the protein, and then the mechanism by which these forms contribute to cancer progression. As a soluble cytokine the ability to reduce or eliminate IL‐16 synthesis through siRNA approaches or bioactivity through the use of neutralizing antibody treatment may represent a novel therapeutic approach. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
Source: Journal of Cellular Physiology - July 29, 2013 Category: Cytology Authors: Jillian Richmond, Marina Tuzova, William Cruikshank, David Center Tags: Mini‐Review Source Type: research