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LIPUS suppressed LPS ‐induced IL‐1α through the inhibition of NF‐κB nuclear translocation via AT1‐PLCβ pathway in MC3T3‐E1
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 6, 2017 Category: Cytology Authors: Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Masako Naito, Kumiko Nakai, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Masao Maeno, Naoto Suzuki, Shuichi Sato Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

TGF‐β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells
Ift88 is an intraflagella transport protein, critical for the cilium, and has been shown to be required for the maintenance of chondrocytes and cartilage. However, how Ift88 is controlled by cytokines that play a role in osteoarthritis is not well understood. Therefore, we examined the effects of TGF‐β on the expression of Ift88. We used ATDC5 cells as chondrocytes and analyzed the effects of TGF‐β on gene expression. TGF‐β treatment suppresses the levels of Ift88 mRNA in a dose‐dependent manner starting from as low as 0.5 ng/mL and reaching the nadir at around 2 ng/mL. TGF‐β treatment also suppresses the...
Source: Journal of Cellular Physiology - July 27, 2015 Category: Cytology Authors: Makiri Kawasaki, Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Yayoi Izu, Masaki Noda Tags: Original Research Article Source Type: research

TGF‐Beta Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - April 1, 2015 Category: Cytology Authors: Makiri Kawasaki, Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Yayoi Izu, Masaki Noda Tags: Original Research Article Source Type: research