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The Androgen Receptor Regulates PPAR γ Expression and Activity in Human Prostate Cancer Cells
The peroxisome proliferator activated receptor gamma (PPARγ) is a ligand‐activated transcription factor that regulates growth and differentiation within normal prostate and prostate cancers. However the factors that control PPARγ within the prostate cancers have not been characterized. The goal of this study was to examine whether the androgen receptor (AR) regulates PPARγ expression and function within human prostate cancer cells. qRT‐PCR and Western blot analyses revealed nanomolar concentrations of the AR agonist dihydrotestosterone (DHT) decrease PPARγ mRNA and protein within the castration‐resistant, AR‐po...
Source: Journal of Cellular Physiology - March 13, 2016 Category: Cytology Authors: Emuejevoke Olokpa, Adrienne Bolden, LaMonica V. Stewart Tags: Original Research Article Source Type: research

The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - March 4, 2016 Category: Cytology Authors: Emuejevoke Olokpa, Adrienne Bolden, LaMonica V. Stewart Tags: Original Research Article Source Type: research

Wild‐type and Specific Mutant Androgen Receptor Mediates Transcription via 17β‐Estradiol in Sex Hormone‐sensitive Cancer Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 23, 2014 Category: Cytology Authors: Takao Susa, Reina Ikaga, Takashi Kajitani, Masayoshi Iizuka, Hiroko Okinaga, Mimi Tamamori‐Adachi, Tomoki Okazaki Tags: Original Research Article Source Type: research

The ZnR/GPR39 Interacts with the CaSR to Enhance Signaling in Prostate and Salivary Epithelia
Abstract Zinc signaling is mediated by the zinc sensing receptor, ZnR, recently suggested to be the same receptor as G‐protein coupled receptor 39, GPR39. However it is unknown if GPR39 is mediating Zn2+‐dependent signaling in prostate and salivary tissue where changes in zinc concentrations are frequent and of physiological significance. Here, we show that GPR39 is mediating Zn2+‐dependent Ca2+ responses and is regulating activity of MAP and PI3 pathways in prostate cancer cells, PC3, and ductal salivary gland cells, HSY. We next ask whether ZnR/GPR39 interacts with other GPCR family members. We find that endogenous...
Source: Journal of Cellular Physiology - November 22, 2013 Category: Cytology Authors: Hila Asraf, Shimrit Salomon, Andrey Nevo, Israel Sekler, Doris Mayer, Michal Hershfinkel Tags: Original Research Article Source Type: research

The interplay of AMP‐activated protein kinase and androgen receptor in prostate cancer cells
Abstract AMP‐activated protein kinase (AMPK) has recently emerged as a potential target for cancer therapy due to the observation that activation of AMPK inhibits tumor cell growth. It is well‐known that androgen receptor (AR) signaling is a major driver for the development and progression of prostate cancer and that downregulation of AR is a critical step in the induction of apoptosis in prostate cancer cells. However, little is known about the potential interaction between AMPK and AR signaling pathways. In the current study, we showed that activation of AMPK by metformin caused decrease of AR protein level through s...
Source: Journal of Cellular Physiology - October 17, 2013 Category: Cytology Authors: Min Shen, Zhen Zhang, Manohar Ratnam, Q. Ping Dou Tags: Rapid Communication Source Type: research