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Combination therapy with KRAS siRNA and EGFR inhibitor AZD8931 suppresses lung cancer cell growth in vitro
Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - August 22, 2018 Category: Cytology Authors: HabibZarredar , ShadiPashapour , KhalilAnsarin , MajidKhalili , RoghayyehBaghban , SafarFarajnia Source Type: research

­­Depletion of Amyloid Precursor Protein (APP) Causes G0 Arrest in Non‐Small Cell Lung Cancer (NSCLC) Cells
We recently reported that Amyloid Precursor Protein (APP) regulates global protein synthesis in a variety of human dividing cells, including non‐small cell lung cancer (NSCLC) cells. More specifically, APP depletion causes an increase of both cap‐ and IRES‐dependent translation. Since growth and proliferation are tightly coupled processes, here, we asked what effects artificial downregulation of APP could have elicited in NSCLC cells proliferation. APP depletion caused a G0/G1 arrest through destabilization of the cyclin‐C protein and reduced pRb phosphorylation at residues Ser802/811. siRNA to cyclin‐C mirrored ...
Source: Journal of Cellular Physiology - February 25, 2015 Category: Cytology Authors: Anna Sobol, Paola Galluzzo, Megan J. Weber, Sara Alani, Maurizio Bocchetta Tags: Original Research Article Source Type: research

Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in nonsmall cell lung cancer (NSCLC) cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 11, 2014 Category: Cytology Authors: Anna Sobol, Paola Galluzzo, Megan J. Weber, Sara Alani, Maurizio Bocchetta Tags: Original Research Article Source Type: research