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Source: Molecular Carcinogenesis

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Total 68 results found since Jan 2013.

Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro
Abstract Hypoxia leads to the upregulation of a variety of genes mediated largely via the hypoxia inducible transcription factor (HIF). Prominent HIF‐regulated target genes such as the vascular endothelial growth factor (VEGF), the glucose transporter 1 (Glut‐1), or erythropoietin (EPO) help to assure survival of cells and organisms in a low oxygenated environment. Here, we are the first to report the hypoxic regulation of the sperm associated antigen 4 (SPAG4). SPAG4 is a member of the cancer testis (CT) gene family and to date little is known about its physiological function or its involvement in tumor biology. A num...
Source: Molecular Carcinogenesis - July 2, 2013 Category: Molecular Biology Authors: Karl Xaver Knaup, Juliana Monti, Thomas Hackenbeck, Tilmann Jobst‐Schwan, Bernd Klanke, Ruth Elisabeth Schietke, Ingrid Wacker, Juergen Behrens, Kerstin Amann, Kai‐Uwe Eckardt, Christina Warnecke, Michael Sean Wiesener Tags: Research Article Source Type: research

EGFR‐mediated Akt and MAPKs signal pathways play a crucial role in patulin‐induced cell proliferation in primary murine keratinocytes via modulation of Cyclin D1 and COX‐2 expression
In this study, we explore the mechanism involve in proliferation of mouse keratinocytes by PAT. Our study revealed that PAT rapidly induces phosphorylation of EGFR, activation of the Ras/MAPKs, and Akt pathways. This in‐turn leads to the activation of NF‐κB/AP‐1 transcription factors which then binds to the promoter region of the cell growth regulatory genes Cyclin D1 and COX‐2 inducing their expression leading ultimately to PMKs proliferation. Inhibition of EGFR or the Ras/MAPKs, PI3/Akt pathways with different pharmacological inhibitors or knockdown of NF‐κB, c‐jun, c‐fos, Cyclin D1, and COX‐2 with siRN...
Source: Molecular Carcinogenesis - June 29, 2013 Category: Molecular Biology Authors: Shamshad Alam, Anu Pal, Rahul Kumar, Premendra D. Dwivedi, Mukul Das, Kausar M. Ansari Tags: Research Article Source Type: research

β‐Caryophyllene oxide Inhibits Constitutive and Inducible STAT3 Signaling Pathway Through Induction of the SHP‐1 Protein Tyrosine Phosphatase
Abstract Constitutive activation of STAT3 is frequently observed and closely linked with proliferation, survival, invasion, metastasis and angiogenesis in tumor cells. In the present study, we investigated whether β‐caryophyllene oxide (CPO), a sesquiterpene isolated primarily from the essential oils of medicinal plants such as guava (Psidium guajava), and oregano (Origanum vulgare L.), can mediate its effect through interference with the STAT3 activation pathway in cancer cells. The effect of CPO on STAT3 activation, associated protein kinases and phosphatase, STAT3‐regulated gene products and apoptosis was investiga...
Source: Molecular Carcinogenesis - June 13, 2013 Category: Molecular Biology Authors: Chulwon Kim, Somi K. Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung‐Hoon Kim, Gautam Sethi, Kwang Seok Ahn Tags: Research Article Source Type: research

CD44/cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients
Abstract Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability of MDR cells is strengthened compared with their parental cells. However, the mechanisms underlying MDR have not been fully elucidated. We found that CD44 and the cellular prion protein (PrPc) were both overexpressed in MDR cells (MCF7/Adr and H69AR). Subsequently, we chose the human breast cancer cell line MCF7/Adr, which is resistant to adriamycin, for further research. We discovered that PrPc physically and functionally interacted with CD44. The knoc...
Source: Molecular Carcinogenesis - May 16, 2013 Category: Molecular Biology Authors: Yuanyuan Cheng, Lili Tao, Jiawen Xu, Qingquan Li, Juan Yu, Yiting Jin, Qi Chen, Zude Xu, Qiang Zou, Xiuping Liu Tags: Research Article Source Type: research

Thromboxane A2 receptor‐mediated release of matrix metalloproteinase‐1 (MMP‐1) induces expression of monocyte chemoattractant protein‐1 (MCP‐1) by activation of protease‐activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells
Abstract Matrix metalloproteinases (MMPs) and monocyte chemoattractant protein‐1 (MCP‐1, CCL2) are known to be upregulated in many tumors. Their roles in tumor invasion and metastasis are being uncovered. How they are related to each other and involved in tumor progression remains to be determined. Earlier it was reported that I‐BOP‐initiated activation of thromboxane A2 receptor (TP) induced the release of MMP‐1, MMP‐3, and MMP‐9 from lung cancer A549 cells overexpressing TPα (A549‐TPα). Herein it was found that MMP‐1, but not MMP‐3 or MMP‐9, induced the expression of MCP‐1 in A549 cells. Conditi...
Source: Molecular Carcinogenesis - March 8, 2013 Category: Molecular Biology Authors: Xiuling Li, Hsin‐Hsiung Tai Tags: Research Article Source Type: research

The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK
Abstract Expression of T antigen (Galbeta1, 3GalNAc) is associated with enhanced metastatic potential and poor prognosis in colorectal cancer. Cosmc is a molecular chaperone required for the formation of an active T‐synthase, which catalyzes the synthesis of T antigen. However, the expression and role of Cosmc in colorectal cancer are still unclear. Here, real‐time PCR showed that overexpression of Cosmc mRNA in colorectal tumors compared with paired non‐tumorous tissues was associated with increased American Joint Committee on Cancer (AJCC) tumor stage. Forced expression of Cosmc in HCT116 cells significantly increa...
Source: Molecular Carcinogenesis - February 6, 2013 Category: Molecular Biology Authors: John Huang, Mei‐Ieng Che, Neng‐Yu Lin, Ji‐Shiang Hung, Yu‐Ting Huang, Wei‐Chou Lin, Hsiu‐Chin Huang, Po‐Huang Lee, Jin‐Tung Liang, Min‐Chuan Huang Tags: Research Article Source Type: research

Decreased expression of kallikrein‐related peptidase 13: Possible contribution to metastasis of human oral cancer
Abstract The human kallikrein‐related peptidase family is comprised of 15 serine protease genes on chromosome 19q13.4 [1]. Our previous microarray analyses showed that the gene kallikrein‐related peptidase 13 (KLK13) was down‐regulated in oral squamous cell carcinoma (OSCC) cell lines. We evaluated the expression status of KLK13 in primary OSCCs and performed functional molecular experiments in OSCC cell lines. In 102 primary tumors studied, KLK13 expression significantly (P < 0.05) decreased compared with matched normal counterparts. Interestingly, KLK13‐negative cases correlated significantly (P < 0...
Source: Molecular Carcinogenesis - February 1, 2013 Category: Molecular Biology Authors: Shunsaku Ishige, Atsushi Kasamatsu, Kenji Ogoshi, Yasuhiro Saito, Katsuya Usukura, Hidetaka Yokoe, Yukinao Kouzu, Hirofumi Koike, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa Tags: Research Article Source Type: research

Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and Alteration of Akt Phosphorylation
Abstract The beneficial effects of omega‐3 fatty acids are believed to be due in part to selective alteration of arachidonate metabolism that involves cyclooxygenase (COX) enzymes. Here we investigated the effect of eicosapentaenoic acid (EPA) on the proliferation of human non‐small cell lung cancer A549 (COX‐2 over‐expressing) and H1299 (COX‐2 null) cells as well as their xenograft models. While EPA inhibited 50% of proliferation of A549 cells at 6.05 µM, almost 80 µM of EPA was needed to reach similar levels of inhibition of H1299 cells. The formation of prostaglandin (PG)E3 in A549 cells was almost three...
Source: Molecular Carcinogenesis - January 31, 2013 Category: Molecular Biology Authors: Peiying Yang, Carrie Cartwright, Diana Chan, Jibin Ding, Edward Felix, Yong Pan, Jihai Pang, Patrea Rhea, Keith Block, Susan M. Fischer, Robert A. Newman Tags: Research Article Source Type: research