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Source: Molecular Carcinogenesis
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Total 68 results found since Jan 2013.
Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial ‐mesenchymal transition (EMT) markers
This study aims to demonstrate expression and potential role of NR5A2 in pancreatic cancer. NR5A2 expression was quantified in resected pancreatic ductal adenocarcinomas and the normal adjacent tissues of 134 patients by immunohistochemistry. The intensity and extent of NR5A2 staining was quantified and analyzed in association with overall survival (OS). The impact of NR5A2 knockdown on pancreatic cancer stem cell (CSC) properties and epithelial‐mesenchymal transition (EMT) markers was examined in cancer cells using RT‐PCR and Western Blot. NR5A2 was overexpressed in pancreatic tumors, the IHC‐staining H score (mean...
Source: Molecular Carcinogenesis - December 19, 2016 Category: Molecular Biology Authors: Zhaofan Luo, Yanan Li, Zuo Mingxin, Chang Liu, Dong Yan, Huamin Wang, Donghui Li Tags: Research Article Source Type: research
The role of metastasis ‐associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression
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Source: Molecular Carcinogenesis - December 19, 2016 Category: Molecular Biology Authors: Shuo Chen, Zhi ‐Hong Zong, Dan‐dan Wu, Kai‐Xuan Sun, Bo‐Liang Liu, Yang Zhao Tags: Research Article Source Type: research
New orally active DNA minor groove binding small molecule CT ‐1 acts against breast cancer by targeting tumor DNA damage leading to p53‐dependent apoptosis
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Source: Molecular Carcinogenesis - October 31, 2016 Category: Molecular Biology Authors: Karan Singh Saini, Hamidullah, Raghib Ashraf, Dhanaraju Mandalapu, Sharmistha Das, Mohd Quadir Siddiqui, Sonam Dwivedi, Jayanta Sarkar, Vishnu Lal Sharma, Rituraj Konwar Tags: Research Article Source Type: research
S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signaling pathway
An elevated level of S100A6 is associated with poor outcomes of many tumor types, but, how S100A6 contributes to nasopharyngeal carcinoma (NPC) progression remains unknown. Here, we investigated the expression and prognostic significance of S100A6 in NPC and explored the molecular mechanisms underlying the role of S100A6 in NPC development. The results showed that S100A6 was markedly up‐regulated in NPC tissues and cell lines compared to paired peritumoral normal tissues and a normal nasopharyngeal epithelial cell line, respectively. In tissues from 92 NPC patients, high S100A6 expression was associated with advanced N...
Source: Molecular Carcinogenesis - September 26, 2016 Category: Molecular Biology Authors: Anchuan Li, Dingbo Shi, Benhua Xu, Jingshu Wang, Yan ‐Lai Tang, WeiWei Xiao, Guanzhu Shen, Wuguo Deng, Chong Zhao Tags: Research Article Source Type: research
S100A6 promotes cell proliferation in human nasopharyngeal carcinoma via the p38/MAPK signalling pathway
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Source: Molecular Carcinogenesis - September 5, 2016 Category: Molecular Biology Authors: Anchuan Li, Dingbo Shi, Benhua Xu, Jingshu Wang, Yan ‐Lai Tang, WeiWei Xiao, Guanzhu Shen, Wuguo Deng, Chong Zhao Tags: Research Article Source Type: research
Prostaglandin E2 stimulates urokinase ‐type plasminogen activator receptor via EP2 receptor‐dependent signaling pathways in human AGS gastric cancer cells
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Source: Molecular Carcinogenesis - July 4, 2016 Category: Molecular Biology Authors: Sen Lian, Yong Xia, Trong Thuan Ung, Pham Ngoc Khoi, Hyun Joong Yoon, Sam Gyu Lee, Kyung Keun Kim, Young Do Jung Tags: Research Article Source Type: research
Prostaglandin E2 stimulates urokinase‐type plasminogen activator receptor via EP2 receptor‐dependent signaling pathways in human AGS gastric cancer cells
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - July 4, 2016 Category: Molecular Biology Authors: Sen Lian, Yong Xia, Trong Thuan Ung, Pham Ngoc Khoi, Hyun Joong Yoon, Sam Gyu Lee, Kyung Keun Kim, Young Do Jung Tags: Research Article Source Type: research
Abrus agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy‐dependent cell death
In conclusion, we established that AGG stimulated cell death by autophagy might be used as an alternative tumor suppressor mechanism in human cervical cancer. This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - May 17, 2016 Category: Molecular Biology Authors: Prashanta Kumar Panda, Birendra Behera, Biswa Ranjan Meher, Durgesh Nandini Das, Subhadip Mukhopadhyay, Niharika Sinha, Prajna Paramita Naik, Bibhas Roy, Joyjyoti Das, Subhankar Paul, Tapas K Maiti, Rajesh Agarwal, Sujit K Bhutia Tags: Research Article Source Type: research
The role and regulatory mechanism of IL‐1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges
Methylation of the neurofibromatosis type 2 (NF2) gene in low‐grade meningioma (WHO grade I) has crucial roles in tumorigenesis and development. Meningioma formation might also occur in the setting of an inflammatory microenvironment. However, the association between inflammation and the methylation of NF2 remains unclear. The present study investigates the role and regulatory mechanism of IL‐1β, one of the most important pro‐inflammatory cytokines, in the methylation of NF2 in benign meningioma. Three primary low‐grade meningioma cells and leptomeningeal cells were cultured. CCK‐8 and BrdU assays demonstrated t...
Source: Molecular Carcinogenesis - February 4, 2016 Category: Molecular Biology Authors: Baofeng Wang, Zhenwen Cui, Zhihong Zhong, Yuhao Sun, Guo‐Yuan Yang, Qingfang Sun, Liuguan Bian Tags: Research Article Source Type: research
The role and regulatory mechanism of IL ‐1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges
Methylation of the neurofibromatosis type 2 (NF2) gene in low‐grade meningioma (WHO grade I) has crucial roles in tumorigenesis and development. Meningioma formation might also occur in the setting of an inflammatory microenvironment. However, the association between inflammation and the methylation of NF2 remains unclear. The present study investigates the role and regulatory mechanism of IL‐1β, one of the most important pro‐inflammatory cytokines, in the methylation of NF2 in benign meningioma. Three primary low‐grade meningioma cells and leptomeningeal cells were cultured. CCK‐8 and BrdU assays demonstrated t...
Source: Molecular Carcinogenesis - February 2, 2016 Category: Molecular Biology Authors: Baofeng Wang, Zhenwen Cui, Zhihong Zhong, Yuhao Sun, Guo ‐Yuan Yang, Qingfang Sun, Liuguan Bian Tags: Research Article Source Type: research
Helicobacter pylori induces Snail expression through ROS‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 26, 2016 Category: Molecular Biology Authors: Hoang‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research
Helicobacter pylori induces Snail expression through ROS ‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 24, 2016 Category: Molecular Biology Authors: Hoang ‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research
A Zbtb7a proto‐oncogene as a novel target for miR‐125a
In our previous study, we showed that miR‐125a directly targeted a WT1 oncogene, which was overexpressed in leukemia and various kinds of solid tumors including lung, breast, gastric, and colon cancers, and brain tumors and was deeply involved in leukemogenesis and tumorigenesis and that miR‐125a knockout mice overexpressed WT1 and developed myeloproliferative disease. It had been also reported that miR‐125a is downregulated in leukemia and various types of solid tumors such as lung cancers, suggesting its tumor suppressor function. Therefore, it is important to elucidate what is target(s) of miR‐125a for understan...
Source: Molecular Carcinogenesis - December 29, 2015 Category: Molecular Biology Authors: Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji Tags: Research Article Source Type: research
A Zbtb7a proto ‐oncogene as a novel target for miR‐125a
In our previous study, we showed that miR‐125a directly targeted a WT1 oncogene, which was overexpressed in leukemia and various kinds of solid tumors including lung, breast, gastric, and colon cancers, and brain tumors and was deeply involved in leukemogenesis and tumorigenesis and that miR‐125a knockout mice overexpressed WT1 and developed myeloproliferative disease. It had been also reported that miR‐125a is downregulated in leukemia and various types of solid tumors such as lung cancers, suggesting its tumor suppressor function. Therefore, it is important to elucidate what is target(s) of miR‐125a for understan...
Source: Molecular Carcinogenesis - December 28, 2015 Category: Molecular Biology Authors: Nozomi Hojo, Naoya Tatsumi, Nahoko Moriguchi, Akihide Matsumura, Soyoko Morimoto, Jun Nakata, Fumihiro Fujiki, Sumiyuki Nishida, Hiroko Nakajima, Akihiro Tsuboi, Yoshihiro Oka, Naoki Hosen, Seiji Hayashi, Haruo Sugiyama, Yusuke Oji Tags: Article Source Type: research
Expression, modulation, and clinical correlates of the autophagy protein Beclin‐1 in esophageal adenocarcinoma
We report for the first time, loss of Beclin‐1, a key mediator of autophagy, was significantly linked to prognostic factors in EAC. Specifically, Beclin‐1 expression loss occurred in 49.0% of EAC patients versus 4.8% of controls. There was a significant inverse correlation between loss of Beclin‐1 with histologic grade and tumor stage supporting a tumor suppressive role for Beclin‐1. Autophagy modulation linked to cell death was examined in EAC cell lines following treatment with a proanthocyanidin‐rich cranberry extract, C‐PAC, and the commonly used autophagy inducer, rapamycin. C‐PAC induced Beclin‐1‐in...
Source: Molecular Carcinogenesis - November 19, 2015 Category: Molecular Biology Authors: Katherine M. Weh, Amy B. Howell, Laura A. Kresty Tags: Brief Communication Source Type: research
