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Lupus Nephritis: Glycogen Synthase Kinase 3β Promotion of Renal Damage Through Activation of the NLRP3 Inflammasome in Lupus‐Prone Mice
ConclusionThese results show that GSK‐3β promotes lupus nephritis at least partly by activating the NLRP3/IL‐1β pathway. The linking of GSK‐3β to the NLRP3/IL‐1β pathway is a novel observation in our study. Our results suggest that the GSK‐3β/NLRP3/IL‐1β pathway may be a potential therapeutic target for lupus in humans.
Source: Arthritis and Rheumatism - March 27, 2015 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

Lupus nephritis: Glycogen synthase kinase 3β promotes renal damage through activation of NLRP3 inflammasome in lupus‐prone mice
Conclusion. These results show that GSK3β promotes LN, at least in part, by activating the NLRP3/IL‐1β pathway. The linking of GSK3β to the NLRP3/IL‐1β pathway is a novel observation in our study. Our results suggest that the GSK3β/NLRP3/IL‐1β pathway may be potential therapeutic targets for human lupus. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 15, 2014 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research