• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Simvastatin Protects Dopaminergic Neurons Against MPP < sup > + < /sup > -Induced Oxidative Stress and Regulates the Endogenous Anti-Oxidant System Through ERK
Conclusion: Our results provide strong evidence that ERK1/2-mediated modulation of the anti-oxidant system after simvastatin treatment may partially explain the anti-oxidant activity in experimental parkinsonian models. These findings contribute to a better understanding of the critical roles of simvastatin via the ERK1/2-mediated modulation of the anti-oxidant system, which may be relevant for treating PD.Cell Physiol Biochem 2018;51:1957 –1968
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppar γ/Lxrα Signaling Pathway-Dependent Manner
Conclusions: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPAR γ/LXRα signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS.Cell Physiol Biochem 2017;43:1703 –1717
Source: Cellular Physiology and Biochemistry - October 18, 2017 Category: Cytology Source Type: research