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Signalling Mechanisms Underlying Doxorubicin And Nox2 Nadph Oxidase ‐Induced Cardiomyopathy: Involvement Of Mitofusin‐2
Conclusions and implicationsDOX‐induced and Nox2‐mediated upregulation of Mfn2, rather than contributing to cardiomyocyte dysfunction through apoptotic pathways, appears to promote a protective mechanism.
Source: British Journal of Pharmacology - March 5, 2017 Category: Drugs & Pharmacology Authors: Declan McLaughlin, Youyou Zhao, Karla M O'Neill, Kevin S Edgar, Philip D Dunne, Anna M Kearney, David J Grieve, Barbara J McDermott Tags: RESEARCH PAPER THEMED ISSUE Source Type: research

Quercetin Attenuates Doxorubicin Cardiotoxicity by Modulating Bmi‐1 Expression
Conclusions And ImplicationsOur results demonstrate that QCT abrogates Dox‐induced cardiotoxicity in vitro and in vivo by reducing oxidative stress by upregulation of Bmi‐1 expression. The novel findings presented in this study have potential applications in preventing Dox‐induced cardiomyopathy.
Source: British Journal of Pharmacology - June 5, 2014 Category: Drugs & Pharmacology Authors: Qinghua Dong, Long Chen, Qunwei Lu, Sherven Sharma, Lei Li, Sachio Morimoto, Guanyu Wang Tags: Research Paper Source Type: research