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Source: Experimental Dermatology

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Total 40 results found since Jan 2013.

Novel nanosome delivery system combined with siRNA targeting the antimicrobial gene DFB4: A new approach for psoriasis management?
This study encourages the exploration of topical gene silencing strategies in dermatology, and refocuses our attention on both, the role of hBD2 in psoriasis pathogenesis, and the thorny question which animal model reflects human psoriasis most faithfully. This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 28, 2014 Category: Dermatology Authors: A Keren, M David, A Gilhar Tags: Commentary from the Editorial Board Source Type: research

Targeted silencing of DEFB4 in a bioengineered skin‐humanized mouse model for psoriasis: development of siRNA SECosome‐based novel therapies
Abstract Psoriasis is a complex inflammatory skin disease that presents a wide variety of clinical manifestations. Human β defensin‐2 (hBD‐2) is highly up‐regulated in psoriatic lesions and has been defined as a biomarker for disease activity. We explored the potential benefits of targeting hBD‐2 by topical application of DEFB4‐siRNA‐containing SECosomes in a bioengineered skin‐humanized mouse model for psoriasis. A significant improvement in the psoriatic phenotype was observed by histological examination, with a normalization of the skin architecture and a reduction in the number and size of blood vessels ...
Source: Experimental Dermatology - March 7, 2014 Category: Dermatology Authors: Stefanie Bracke, Marta Carretero, Sara Guerrero‐Aspizua, Eline Desmet, Nuria Illera, Manuel Navarro, Jo Lambert, Marcela Del Rio Tags: Letter to the Editor Source Type: research

Targeted silencing of DEFB4 in a bio‐engineered skin‐humanised mouse model for psoriasis: development of siRNA SECosome‐based novel therapies
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - January 1, 2014 Category: Dermatology Authors: S. Bracke, M. Carretero, S. Guerrero‐Aspizua, E. Desmet, N. Illera, M. Navarro, J. Lambert, Marcela Del Rio Tags: Letter to the editor Source Type: research

Notch‐1 mediates endothelial cell activation and invasion in Psoriasis
ConclusionNotch‐receptor‐ligand interactions mediate vascular dysfunction in Psoriasis and may represent a potential therapeutic target.This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - December 1, 2013 Category: Dermatology Authors: Peadar Rooney, Mary Connolly, Wei Gao, Jennifer McCormick, Monika Biniecka, Owen Sullivan, Brian Kirby, Cheryl Sweeney, Eamonn Molloy, Trevor Markham, Ursula Fearon, Douglas J Veale Tags: Regular Article Source Type: research

Deranged epidermal differentiation in kl/kl mouse and the effects of βKlotho siRNA on the differentiation of HaCaT cells
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - October 7, 2013 Category: Dermatology Authors: Kozo Nakai, Kozo Yoneda, Reiji Haba, Yoshio Kushida, Naomi Katsuki, Tetsuya Moriue, Hiroaki Kosaka, Yasuo Kubota, Shigeaki Inoue Tags: Letter Source Type: research

Expressions of peroxisome proliferator‐activated receptors (PPARs) are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes
In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD.
Source: Experimental Dermatology - August 16, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Expressions of PPARs are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes
In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD. This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - June 29, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Resveratrol Induces Autophagy Through Death‐Associated Protein Kinase 1 (DAPK1) In Human Dermal Fibroblasts Under Normal Culture Conditions
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - May 23, 2013 Category: Dermatology Authors: Min Sik Choi, Yoonkyung Kim, Ji‐Yong Jung, Seung Ha Yang, Tae Ryong Lee, Dong Wook Shin Tags: Letter to the Editor Source Type: research

E‐FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro
Abstract Epidermal fatty acid‐binding protein (E‐FABP) is a lipid carrier, originally discovered in human epidermis. We show that E‐FABP is almost exclusively expressed in post mitotic (PM) keratinocytes, corresponding to its localization in the highest suprabasal layers, while it is barely expressed in keratinocyte stem (KSC) and transit amplifying (TA) keratinocytes. Transfection of normal human keratinocytes with recombinant (r) E‐FABP induces overexpression of K10 and involucrin. On the other hand, E‐FABP inhibition by siRNA downregulates K10 and involucrin expression in normal keratinocytes through NF‐κB ...
Source: Experimental Dermatology - February 11, 2013 Category: Dermatology Authors: K Dallaglio, A Marconi, F Truzzi, R Lotti, E Palazzo, T Petrachi, A Saltari, M Coppini, C Pincelli Tags: Regular Article Source Type: research

Wnt5a attenuates Wnt/β‐catenin signaling in human dermal papilla cells
Abstract Findings of recent studies have demonstrated modulation of Wnt/β‐catenin signaling by Wnt5a, which is highly expressed in hair follicular dermal papilla (DP) in vivo. Here we investigated the question of whether Wnt5a can affect canonical Wnt/β‐catenin signaling in DP cells. Treatment with Wnt5a resulted in attenuation of Wnt3a‐mediated elevation of β‐catenin signaling, which was increased by Wnt5a siRNA transfection in cultured DP cells, as examined by reporter assay. In addition, treatment with Wnt5a resulted in repressed Wnt3a‐mediated expression of Axin2, EP2, and LEF1 in cultured DP cells whereas...
Source: Experimental Dermatology - January 1, 2013 Category: Dermatology Authors: Mi Hee Kwack, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung Tags: Letter to the Editors Source Type: research