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Source: Experimental Dermatology

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Total 40 results found since Jan 2013.

Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR ‐2 protein half‐life in part via a VE‐cadherin dependent mechanism
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Source: Experimental Dermatology - July 31, 2016 Category: Dermatology Authors: Igor Hrgovic, Monika Doll, Andreas Pinter, Roland Kaufmann, Stefan Kippenberger, Markus Meissner Tags: Regular Article Source Type: research

Long non‐coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization
Abstract Long non‐coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real‐time PCR and in situ hybridization. Protein and mRNA levels of collagen were analysed using immunoblotting and real‐time PCR. We found TSIX, one of the lncRNAs, was overexpressed in SSc dermal fibroblasts both in vivo and in vitro, which was inhibited by the transfection of transforming growth factor (TGF)...
Source: Experimental Dermatology - January 12, 2016 Category: Dermatology Authors: Zhongzhi Wang, Masatoshi Jinnin, Kayo Nakamura, Miho Harada, Hideo Kudo, Wakana Nakayama, Kuniko Inoue, Taiji Nakashima, Noritoshi Honda, Satoshi Fukushima, Hironobu Ihn Tags: Original Article Source Type: research

Long non‐coding RNA TSIX is up‐regulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization
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Source: Experimental Dermatology - November 14, 2015 Category: Dermatology Authors: Zhongzhi Wang, Masatoshi Jinnin, Kayo Nakamura, Miho Harada, Hideo Kudo, Wakana Nakayama, Kuniko Inoue, Taiji Nakashima, Noritoshi Honda, Satoshi Fukushima, Hironobu Ihn Tags: Regular Article Source Type: research

Sirtuin‐6 deficiency exacerbates diabetes‐induced impairment of wound healing
Abstract Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous pathophysiological processes, including those involved in promotion of longevity, DNA repair, glycolysis and inflammation. However, the role of sirtuin 6 (SIRT6), a NAD+‐dependent nuclear deacetylase, in wound healing specifically under diabetic condition remains unclear. To analyse the role of SIRT6 in cutaneous wound healing, paired 6‐mm stented wound was created in diabetic db/db mice...
Source: Experimental Dermatology - August 18, 2015 Category: Dermatology Authors: Rajarajan A. Thandavarayan, Venkata Naga Srikanth Garikipati, Darukeshwara Joladarashi, Sahana Suresh Babu, Prince Jeyabal, Suresh K. Verma, Alexander R. Mackie, Mohsin Khan, Somasundaram Arumugam, Kenichi Watanabe, Raj Kishore, Prasanna Krishnamurthy Tags: Original Article Source Type: research

Dual oxidase 2 is essential for house dust mite‐induced pro‐inflammatory cytokine production in human keratinocytes
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Source: Experimental Dermatology - July 1, 2015 Category: Dermatology Authors: Eunbi Ko, Hyun Choi, Kkot‐Nara Park, Ju‐Yearl Park, Tae Ryong Lee, Dong Wook Shin, Yun Soo Bae Tags: Regular Article Source Type: research

Global DNA hypomethylation and hypoxia‐induced expression of the ten eleven translocation (TET) family, TET1, in scleroderma fibroblasts
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Source: Experimental Dermatology - May 25, 2015 Category: Dermatology Authors: Mai Hattori, Yoko Yokoyama, Tomoyasu Hattori, Sei‐ichiro Motegi, Hiroo Amano, Izuho Hatada, Osamu Ishikawa Tags: Regular Article Source Type: research

Sirtuin‐6 deficiency exacerbates diabetes induced impairment of wound healing
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Source: Experimental Dermatology - May 23, 2015 Category: Dermatology Authors: Rajarajan A Thandavarayan, Venkata Naga Srikanth Garikipati, Joladarashi Darukeshwara, Sahana Suresh Babu, Prince Jeyabal, Suresh K Verma, Alexander R Mackie, Mohsin Khan, Somasundaram Arumugam, Kenichi Watanabe, Raj Kishore, Prasanna Krishnamurthy Tags: Regular Article Source Type: research

In vivo relative quantitative proteomics reveals HMGB1 as a downstream mediator of oestrogen‐stimulated keratinocyte migration
Abstract It is known that oestrogen influences skin wound healing by modulating the inflammatory response, cytokine expression and extracellular matrix deposition; accelerating re‐epithelialization; and stimulating angiogenesis. To identify novel proteins associated with effects of oestrogen on keratinocyte, stable isotope labelling by amino acids in cell culture (SILAC)‐based mass spectrometry was performed. Using SILAC, quantification of 1085 proteins was achieved. Among these proteins, 60 proteins were upregulated and 32 proteins were downregulated. Among significantly upregulated proteins, high‐mobility group pro...
Source: Experimental Dermatology - April 27, 2015 Category: Dermatology Authors: Jung U Shin, Ji Yeon Noh, Ju Hee Lee, Won Jai Lee, Jong Shin Yoo, Jin Young Kim, Hyeran Kim, Inhee Jung, Shan Jin, Kwang Hoon Lee Tags: Letter to the Editor Source Type: research

EMMPRIN regulates β1 integrin‐mediated adhesion through Kindlin‐3 in human melanoma cells
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Source: Experimental Dermatology - March 21, 2015 Category: Dermatology Authors: Julie Delyon, Farah Khayati, Ibtissem Djaafri, Marie‐Pierre Podgorniak, Aurélie Sadoux, Niclas Setterblad, Zineb Boutalbi, Kamel Maouche, Uwe Maskos, Suzanne Menashi, Céleste Lebbé, Samia Mourah Tags: Regular Article Source Type: research

Aldo‐keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism
Abstract Aldo‐keto reductase 1C3 (AKR1C3) is an enzyme involved in metabolizing prostaglandins (PGs) and sex hormones. It metabolizes PGD2 to 9α11β‐PGF2, diverting the spontaneous conversion of PGD2 to the PPARγ agonist, 15‐Deoxy‐Delta‐12, 14‐prostaglandin J2 (15d‐PGJ2). AKR1C3 is overexpressed in various malignancies, suggesting a tumor promoting function. This work investigates AKR1C3 expression in human non‐melanoma skin cancers, revealing overexpression in squamous cell carcinoma (SCC). Effects of AKR1C3 overexpression were then evaluated using three SCC cell lines. AKR1C3 was detected in all SCC cel...
Source: Experimental Dermatology - July 16, 2014 Category: Dermatology Authors: Alon Mantel, Amanda Carpenter‐Mendini, JoAnne VanBuskirk, Alice P. Pentland Tags: Original Article Source Type: research

P2Y2R activation by nucleotides promotes skin wound‐healing process
This study aimed to investigate the role of P2Y2R in the wound‐healing process and the mechanisms by which P2Y2R activation promotes wound healing in fibroblasts. The role of P2Y2R in skin wound healing was examined using a full‐thickness skin wound model in wildtype (WT) and P2Y2R−/− mice and an in vitro scratch wound model in control or P2Y2R siRNA‐transfected fibroblasts. WT mice showed significantly decreased wound size compared with P2Y2R−/− mice at day 14 post‐wounding, and immunohistochemical analysis showed that a proliferation marker Ki67 and extracellular matrix (ECM)‐related proteins VEGF, coll...
Source: Experimental Dermatology - July 16, 2014 Category: Dermatology Authors: Hana Jin, Jihye Seo, So Young Eun, Young Nak Joo, Sang Won Park, Jae Heun Lee, Ki Churl Chang, Hye Jung Kim Tags: Original Article Source Type: research

NADPH oxidase‐2 is a key regulator of human dermal fibroblasts: a potential therapeutic strategy for the treatment of skin fibrosis
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Source: Experimental Dermatology - June 30, 2014 Category: Dermatology Authors: Guo‐You Zhang, Liang‐Cai Wu, Tao Dai, Shi‐Yi Chen, An‐Yuan Wang, Kang Lin, Da‐Mu Lin, Jing‐Quan Yang, Biao Cheng, Li Zhang, Wei‐Yang Gao, Zhi‐Jie Li Tags: Regular Article Source Type: research

Aldo‐keto Reductase 1C3 (AKR1C3) is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - June 10, 2014 Category: Dermatology Authors: Alon Mantel, Amanda Carpenter‐Mendini, JoAnne VanBuskirk, Alice P. Pentland Tags: Regular Article Source Type: research

SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7
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Source: Experimental Dermatology - May 21, 2014 Category: Dermatology Authors: S. Wang, S. Olt, N. Schoefmann, A. Stuetz, A. Winiski, B. Wolff‐Winiski Tags: Letter to the Editors Source Type: research

P2Y2R activation by nucleotides promotes skin wound healing process
This study aimed to investigate the role of P2Y2R in the wound‐healing process and the mechanisms by which P2Y2R activation promotes wound‐healing in fibroblasts. The role of P2Y2R in skin wound‐healing was examined using a full‐thickness skin‐wound model in wildtype (WT) and P2Y2R‐/‐ mice and an in vitro scratch‐wound model in control‐ or P2Y2R‐siRNA‐transfected fibroblasts. WT mice showed significantly decreased wound size compared with P2Y2R‐/‐ mice at day 14 post‐wounding, and immunohistochemical analysis showed that a proliferation marker Ki67 and extracellular matrix (ECM)‐related protei...
Source: Experimental Dermatology - May 11, 2014 Category: Dermatology Authors: Hana Jin, Jihye Seo, So Young Eun, Young Nak Joo, Sang Won Park, Jae Heun Lee, Ki Churl Chang, Hye Jung Kim Tags: Regular Article Source Type: research