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Source: Experimental Dermatology
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Total 40 results found since Jan 2013.
The absence of Rab27a accelerates the degradation of Melanophilin
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - November 12, 2018 Category: Dermatology Authors: Jong il Park,
Ji Eun Lee,
Cheol hwan Myung,
Chan song Jo,
Hye Sung Jang,
Jae Sung Hwang Tags: Methods Letter to the Editors Source Type: research
The siRNA ‐mediated downregulation of PD‐1 alone or simultaneously with CTLA‐4 shows enhanced in vitro CAR‐T‐cell functionality for further clinical development towards the potential use in immunotherapy of melanoma
Experimental Dermatology,Volume 27, Issue 7, Page 769-778, July 2018.
Source: Experimental Dermatology - June 28, 2018 Category: Dermatology Authors: Bianca
Simon
,
Dennis C.
Harrer
,
Beatrice
Schuler ‐Thurner
,
Niels
Schaft
,
Gerold
Schuler
,
Jan
Dörrie
,
Ugur
Uslu Source Type: research
The siRNA ‐mediated downregulation of PD‐1 alone or simultaneously with CTLA‐4 shows enhanced in‐vitro CAR‐T cell functionality for further clinical development towards the potential use in immunotherapy of melanoma
Experimental Dermatology,Volume 0, Issue ja, -Not available-.
Source: Experimental Dermatology - April 28, 2018 Category: Dermatology Authors: Bianca Simon
,
Dennis C Harrer
,
Beatrice Schuler ‐Thurner
,
Niels Schaft
,
Gerold Schuler
,
Jan Dörrie
,
Ugur Uslu Source Type: research
IL ‐26 in allergic contact dermatitis: resource in a state of readiness
In conclusion, our findings support the idea that this emergent cytokine, IL‐26, is implicated in the killing mechanisms of KC observed during ACD.
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 2, 2018 Category: Dermatology Authors: Giuseppina Caiazzo, Roberta Di Caprio, Serena Lembo, Annunziata Raimondo, Emanuele Scala, Cataldo Patruno, Anna Balato Tags: Methods Letter to the Editors Source Type: research
Transcriptomic analysis of FUCA1 knockdown in keratinocytes reveals new insights in the pathogenesis of fucosidosis skin lesions
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - February 1, 2018 Category: Dermatology Authors: Danyela Valero ‐Rubio, Karen Marcela Jiménez, Dora Janeth Fonseca, César Payán‐Gomez, Paul Laissue Tags: Regular Article Source Type: research
Towards the development of a RNAi ‐based topical treatment for psoriasis: Proof‐of‐concept in a 3D psoriasis skin model
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - August 20, 2017 Category: Dermatology Authors: Desmet Eline, Mireille Van Gele, Lynda Grine, Katrien Remaut, Jo Lambert Tags: Regular Article Source Type: research
The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis
Abstract
The insufficiency of Friend leukaemia virus integration 1 (Fli1), a member of the Ets family transcription factors, is implicated in the pathogenesis of vasculopathy associated with systemic sclerosis (SSc). Fli1 deficiency accelerates early steps of angiogenesis, including detachment of pre‐existing pericytes and extracellular matrix degradation by endothelial proteinases, but the impact of Fli1 deficiency on the other steps of angiogenesis has not been investigated. Therefore, we evaluated the effect of Fli1 deficiency on migration, proliferation, cell survival and tube formation of human dermal microvascular ...
Source: Experimental Dermatology - July 10, 2017 Category: Dermatology Authors: Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato Tags: ORIGINAL ARTICLE Source Type: research
An efficient method for gene knock ‐down by RNA interference in human skin mast cells
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - April 18, 2017 Category: Dermatology Authors: Tarek Hazzan, Sven Guhl, Metin Artuc, Kristin Franke, Margitta Worm, Torsten Zuberbier, Magda Babina Tags: Methods Letter to the Editors Source Type: research
Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signalling pathway via GSK‐3β inactivation
Abstract
Vitiligo is an acquired condition characterized by depigmented, cutaneous lesions that result from the death of pigment‐producing cells, melanocytes. The occurrence of oxidative stress has been proposed as a pathogenetic mechanism for melanocyte degeneration in vitiligo. Therefore, in this study, we investigated the cytoprotective effects of afzelin against oxidative stress and its mechanism of action in human epidermal melanocytes. We found that afzelin significantly inhibited hydrogen peroxide‐induced cell death, cellular reactive oxygen species production and lipid peroxidation in melanocytes. In an antioxi...
Source: Experimental Dermatology - April 11, 2017 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: ORIGINAL ARTICLE Source Type: research
The impact of transcriptional factor Fli1 deficiency on the regulation of angiogenesis
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 31, 2017 Category: Dermatology Authors: Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato Tags: Regular Article Source Type: research
Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL) ‐1β and IL‐18 release
In conclusion, the NLRP3 inflammasome can act as a sensor of dsRNA in epidermal keratinocytes, which may be important in both skin innate immune defense against viral infection and skin inflammation.
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 6, 2017 Category: Dermatology Authors: Xiuju Dai, Mikiko Tohyama, Masamoto Murakami, Koji Sayama Tags: Regular Article Source Type: research
Melanocyte ‐protective effect of afzelin is mediated by the Nrf2‐ARE signaling pathway via GSK‐3β inactivation
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - December 18, 2016 Category: Dermatology Authors: Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee Tags: Regular Article Source Type: research
IL ‐17F regulates psoriasis‐associated genes through IκBζ
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - August 29, 2016 Category: Dermatology Authors: Trine Bertelsen, Christine Ljungberg, Rasmus Boye Kjellerup, Lars Iversen, Claus Johansen Tags: Regular Article Source Type: research
Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - August 29, 2016 Category: Dermatology Authors: Heba Dosoki, Agatha Stegemann, Muna Taha, Hans Schnittler, Thomas A. Luger, Katrin Schr öder, Jörg H. W. Distler, Claus Kerkhoff, Markus Böhm Tags: Regular Article Source Type: research
