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Source: Acta Biochimica et Biophysica Sinica
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Total 83 results found since Jan 2013.
Resveratrol induces proliferation in preosteoblast cell MC3T3-E1 via GATA-1 activating autophagy
We examined the cell viability, colony formation, cell cyclin expression, autophagy level, and the expression levels of GATA-1 and adenosine 5'-monophosphate (AMP)-activated protein kinase α (AMPKα) in osteoblastic cell strain MC3T3-E1. The results showed that RSV promoted the proliferation process in MC3T3-E1 coupled with increased expression of GATA-1 and phosphorylated AMPKα and activated autophagy. When GATA-1 was interfered with siRNA, both autophagy and proliferation were decreased. Administration of the agonist of phosphorylated AMPKα1 (Thr172) promoted the translocation of GATA-1 into the nucleus. Based on the ...
Source: Acta Biochimica et Biophysica Sinica - October 12, 2021 Category: Biochemistry Authors: Xiang Liu Jun Tao Yueyi Yao Ping Yang Juhui Wang Mali Yu Jianhong Hou Ying Zhang L I Gui Source Type: research
Chromobox homolog 4 overexpression inhibits TNF- α-induced matrix catabolism and senescence by suppressing activation of the NF-κB signaling pathway in nucleus pulposus cells
This study may provide new approaches for preventing and treating IDD.PMID:35880565 | DOI:10.3724/abbs.2022063
Source: Acta Biochimica et Biophysica Sinica - July 26, 2022 Category: Biochemistry Authors: Yangyang Zhang Shuangxing Li Junmin Hong Jiansen Yan Zhengqi Huang Jiajun Wu Zhihuai Deng Tianyu Qin Kang Xu Wei Ye Source Type: research
Induction of the ER stress response in NRVMs is linked to cardiotoxicity caused by celastrol
In this study, we explore celastrol's cardiotoxicity using the methods of histology and cell biology. The results show that celastrol administration dose-dependently induces cardiac dysfunction in mice as manifested by left ventricular dilation, myocardial interstitial fibrosis, and cardiomyocyte hypertrophy. Exposure to celastrol greatly decreases neonatal rat ventricular myocyte (NRVM) viability and promotes its apoptosis. More importantly, we demonstrate that celastrol exerts its pro-apoptotic effects through endoplasmic reticulum (ER) stress and unfolded protein response. Furthermore, siRNA targeting C/EBP homologous p...
Source: Acta Biochimica et Biophysica Sinica - August 19, 2022 Category: Biochemistry Authors: Zhong Chen Zhong Zhuang Chen Meng Zhonghua Zhu Yin Zhang Zhao Zhang Source Type: research
Caveolin-1-deficient fibroblasts promote migration, invasion, and stemness via activating the TGF- β/Smad signaling pathway in breast cancer cells
This study refreshingly points out that CAV-1 deficiency in fibroblasts enhances TGF-β1 secretion and then activates the TGF-β1/Smad signaling pathway of BCCs, thus promoting the metastasis and stemness of BCCs. Collectively, our findings indicate an unexpected role of CAV-1 deficiency in fibroblasts and the tumor microenvironment as a permissive factor, which is regulated by the TGF-β1 signaling pathway in BCCs.PMID:36604141 | DOI:10.3724/abbs.2022150
Source: Acta Biochimica et Biophysica Sinica - January 5, 2023 Category: Biochemistry Authors: Qingyun Huang Longyuan Wu Yi Wang Xinyu Kong Xinhua Xiao Qiyuan Huang Miao Li Yujia Zhai Fuxiu Shi Ruichen Zhao Junpei Zhong Lixia Xiong Source Type: research
