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Vascular endothelial growth factor is an autocrine growth factor, signalling through neuropilin-1 in non-small cell lung cancer
Conclusions: Our data demonstrate that VEGF is an autocrine growth factor in NSCLC signaling, at least in part, through NP1. Targeting this VEGF receptor may offer potential as a novel therapeutic approach and also support the evaluation of the role of NP1 as a biomarker predicting sensitivity or resistance to VEGF and VEGFR-targeted therapies in the clinical arena.
Source: Molecular Cancer - February 20, 2015 Category: Cancer & Oncology Authors: Martin BarrSteven GrayKathy GatelyEmily HamsPadraic FallonAnthony DaviesDerek RichardGraham PidgeonKenneth O¿Byrne Source Type: research

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor
Conclusions: These data identify RPTP?/? as a cell membrane binding partner for VEGF that regulates angiogenic functions of endothelial cells and suggest that it warrants further validation as a potential target for development of additive or alternative anti-VEGF therapies.
Source: Molecular Cancer - February 3, 2015 Category: Cancer & Oncology Authors: Marina KoutsioumpaEvangelia PoimenidiEvangelia PantazakaChristina TheodoropoulouAngeliki SkouraVasileios MegalooikonomouNelly KiefferJose CourtyShuji MizumotoKazuyuki SugaharaEvangelia Papadimitriou Source Type: research