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Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells
Conclusions: Our data indicate PTEN as a key target of Bergapten action in breast cancer cells for the induction of autophagy. These findings add further details on the mechanism of action of Bergapten, therefore suggesting that phytochemical compounds may be implemented in the novel strategies for breast cancer treatment.
Source: Molecular Cancer - July 7, 2015 Category: Cancer & Oncology Authors: Francesca De AmicisSaveria AquilaCatia MorelliCarmela GuidoMarta SantoroIda PerrottaLoredana MauroFrancesca GiordanoAlessandra NigroSebastiano AndòMaria Panno Source Type: research

Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells
Conclusion: Cell surface proteoglycans, notably syndecan-2, may be important regulators of breast carcinoma progression through regulation of cytoskeleton, cell adhesion and invasion.
Source: Molecular Cancer - January 27, 2015 Category: Cancer & Oncology Authors: Hooi LimHinke MulthauptJohn Couchman Source Type: research

MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer
Conclusions: Endocrine resistant cells overexpress MYC and are better adapted to withstand periods of glucose deprivation and can use glutamine in the short term to maintain adequate metabolism to support cell survival. Our findings reveal a unique role for MYC in regulating cell fate through the UPR, and suggest that targeting glutamine metabolism may be a novel strategy in endocrine resistant breast cancer.
Source: Molecular Cancer - October 23, 2014 Category: Cancer & Oncology Authors: Ayesha Shajahan-HaqKatherine CookJessica Schwartz-RobertsAhreej EltayebDiane DemasAnni WarriCaroline FaceyLeena Hilakivi-ClarkeRobert Clarke Source Type: research

Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer
Conclusions: Sunitinib induced hypoxia in TNBCs, and Twist1 expression induced by hypoxia accelerated VM by increasing population of CD133+ cells. VM was responsible for the regrowth of TNBCs sunitinib administration was terminated.
Source: Molecular Cancer - September 8, 2014 Category: Cancer & Oncology Authors: Danfang ZhangBaocun SunXiulan ZhaoYuemei MaRu JiQiang GuXueyi DongJing LiFang LiuXiaohua JiaXue LengChong ZhangRan SunJiadong Chi Source Type: research

The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
Conclusions: These results demonstrate coupling of CXCR7 with EGFR to regulate proliferation of BrCa cells and suggest an important ligand-independent role of CXCR7 in BrCa growth. Thus, the CXCR7-EGFR axis is a promising target for breast cancer therapy.
Source: Molecular Cancer - August 28, 2014 Category: Cancer & Oncology Authors: Nicole SalazarDaniel MuñozGeorgios KallifatidisRajendra SinghMercè JordàBal Lokeshwar Source Type: research

Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
Conclusion: We could firstly show that SFRP1 strongly correlates with the triple negative breast cancer subtype and secondly, that SFRP1 might be used as a marker stratifying patients to positively respond to neoadjuvant chemotherapy. The mechanisms by which tumor suppressor SFRP1 influences carcinogenic properties of cancer cells do not rely on Wnt signaling, thereby demonstrating the complexity of tumor associated signaling pathways.
Source: Molecular Cancer - July 17, 2014 Category: Cancer & Oncology Authors: Christof BernemannCarolin HülsewigChristian RuckertSarah SchäferLena BlümelGeorg HempelMartin GötteBurkhard GrevePeter BarthLudwig KieselCornelia Liedtke Source Type: research

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation
Conclusions: As a novel Hsp90 inhibitor, FW-04-806 binds to the N-terminal of Hsp90 and inhibits Hsp90/Cdc37 interaction, resulting in the disassociation of Hsp90/Cdc37/client complexes and the degradation of Hsp90 client proteins. FW-04-806 displays promising antitumor activity against breast cancer cells both in vitro and in vivo, especially for HER2-overexpressed breast cancer cells.
Source: Molecular Cancer - June 14, 2014 Category: Cancer & Oncology Authors: Wei HuangMin YeLian-ru ZhangQun-dan WuMin ZhangJian-hua XuWei Zheng Source Type: research

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
Conclusions: Integrated analysis of microRNA, mRNA and ChIP-seq data in a model cell line supports the hypothesis that microRNA expression under hypoxia is regulated at transcriptional and post-transcriptional level, with the presence of HIF binding sites at microRNA genomic loci associated with up-regulation. The identification of hypoxia and HIF regulated microRNAs relevant for breast cancer is important for our understanding of disease development and design of therapeutic interventions.
Source: Molecular Cancer - February 11, 2014 Category: Cancer & Oncology Authors: Carme CampsHarpreet SainiDavid MoleHani ChoudhryMartin ReczkoJosé Afonso Guerra-AssunçãoYa-Min TianFrancesca BuffaAdrian HarrisArtemis HatzigeorgiouAnton EnrightJiannis Ragoussis Source Type: research