• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype
Conclusions: Our results establish a link between aberrant P-cadherin expression and hypoxic, glycolytic and acid-resistant breast cancer cells, suggesting a possible role for this marker in cancer cell metabolism.
Source: BMC Cancer - October 1, 2014 Category: Cancer & Oncology Authors: Bárbara SousaAna RibeiroAna NobreNair LopesDiana MartinsCéline PinheiroAndré VieiraAndré AlbergariaRené GerhardFernando SchmittFátima BaltazarJoana Paredes Source Type: research

YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells
Conclusions: To conclude, in a subset of BC cells, namely RR cells, YB-1 regulates Sox2 to coordinately maintain stemness and tumorigenic properties.
Source: BMC Cancer - May 9, 2014 Category: Cancer & Oncology Authors: Karen JungFang WuPeng WangXiaoxia YeBassam AbdulkarimRaymond Lai Source Type: research

Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity
Conclusion: Sox2 regulates the invasiveness of BC cells via a mechanism that is dependent on Twist1 and the transcriptional status of Sox2. Our results have further highlighted a new level of biological complexity and heterogeneity of BC cells that may carry significant clinical implications.
Source: BMC Cancer - July 1, 2013 Category: Cancer & Oncology Authors: Fang WuXiaoxia YePeng WangKaren JungChengsheng WuDonna DouglasNorman KnetemanGilbert BigrasYupo MaRaymond Lai Source Type: research