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Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.
CONCLUSION: These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis. PMID: 28246472 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 13, 2017 Category: Gastroenterology Authors: Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP Tags: World J Gastroenterol Source Type: research

Melatonin ‐induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 1, 2016 Category: Research Authors: N éstor Prieto‐Domínguez, Raquel Ordóñez, Anna Fernández, Carolina Méndez‐Blanco, Anna Baulies, Carmen Garcia‐Ruiz, José C. Fernández‐Checa, José L. Mauriz, Javier González‐Gallego Tags: Original Article Source Type: research