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GSE106199 MicroRNA differencial expression data between scrambled siRNA-treated mice and HN1L siRNA-treated mice tumor samples
Contributors : Jenny C Chang ; Olivier Elemento ; Akanksha Verma ; Yi Liu ; Dong S Choi ; Helen WongSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic construct(HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple negative breast cancer (TNBC) patients. HN1L silencing reduced the population of BCSCs, inhibited tumor initiation, re-sensitized chemo-resistant tumors to docetaxel, and hindered cancer progression in multiple TNBC cell line derived xenografts.We ...
Source: GEO: Gene Expression Omnibus - December 20, 2017 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research

GSE106106 mRNA differencial expression data between scrambled siRNA-treated mice and HN1L siRNA-treated mice tumor samples
Contributors : Jenny C Chang ; Stephen Wong ; Yi Liu ; Dong S Choi ; Helen Wong ; Yang Cong ; Jianting ShengSeries Type : Expression profiling by arrayOrganism : Homo sapiens(HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple negative breast cancer (TNBC) patients. HN1L silencing reduced the population of BCSCs, inhibited tumor initiation, re-sensitized chemo-resistant tumors to docetaxel, and hindered cancer progression in multiple TNBC cell line derived xenografts.We used microarray to...
Source: GEO: Gene Expression Omnibus - December 20, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research