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Specialty: Biomedical Science
Drug: Propofol
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Total 2 results found since Jan 2013.
Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPAR γ/STAT3 signaling
Aging (Albany NY). 2021 Jun 10;13. doi: 10.18632/aging.203107. Online ahead of print.ABSTRACTPropofol (Pro) confers protection against renal ischemia/reperfusion (rI/R) injury through incompletely characterized mechanisms. Since Pro has shown net anti-inflammatory properties as part of its beneficial effects, we examined the potential role of Pro in the modulation of macrophage polarization status during both rI/R injury in vivo and exposure of cultured peritoneal macrophages (PMs) to hypoxia/reoxygenation (H/R). Rats were subjected to 45-min r/IR surgery or a sham procedure and administered PBS (vehicle) or Pro during the...
Source: Aging - June 10, 2021 Category: Biomedical Science Authors: Zhaohui Liu Yanli Meng Yu Miao Lili Yu Qianjie Wei Yuqing Li Bing Zhang Qiannan Yu Source Type: research
Propofol Attenuates Lipopolysaccharide-Induced Reactive Oxygen Species Production Through Activation of Nrf2/GSH and Suppression of NADPH Oxidase in Human Alveolar Epithelial Cells
In conclusion, propofol reduced LPS-induced ROS production via inhibition of inflammatory factors and enhancement of Nrf2-related antioxidant defense, providing its cytoprotective evidence under inflammatory conditions.
Source: Inflammation - October 23, 2014 Category: Biomedical Science Source Type: research
