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Cancer: Ovarian Cancer
Drug: Ketoconazole
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Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cells.
In conclusion, inhibition of PXR-mediated pathways could be a novel means of augmenting sensitivity, or overcoming resistance to anticancer agents for ovarian cancer.
PMID: 27572875 [PubMed - in process]
Source: International Journal of Oncology - August 31, 2016 Category: Cancer & Oncology Authors: Masuyama H, Nakamura K, Nobumoto E, Hiramatsu Y Tags: Int J Oncol Source Type: research