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Aspirin induces Nrf2‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress
Abstract The removal of hydrogen peroxide (H2O2) by antioxidants has been proven to be beneficial to patients with vitiligo. Aspirin (acetylsalicylic acid, ASA) has antioxidant activity and has great preventive and therapeutical effect in many oxidative stress‐relevant diseases. Whether ASA can protect human melanocytes against oxidative stress needs to be further studied. Here, we investigated the potential protective effect and mechanisms of ASA against H2O2‐induced oxidative injury in human melanocytes. Human melanocytes were pre‐treated with different concentrations of ASA, followed by exposure to 1.0 mM H2O2. Ce...
Source: Journal of Cellular and Molecular Medicine - March 10, 2016 Category: Molecular Biology Authors: Zhe Jian, Lingzhen Tang, Xiuli Yi, Bangmin Liu, Qian Zhang, Guannan Zhu, Gang Wang, Tianwen Gao, Chunying Li Tags: Original Article Source Type: research

Aspirin induces Nrf2 ‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress
Abstract The removal of hydrogen peroxide (H2O2) by antioxidants has been proven to be beneficial to patients with vitiligo. Aspirin (acetylsalicylic acid, ASA) has antioxidant activity and has great preventive and therapeutical effect in many oxidative stress‐relevant diseases. Whether ASA can protect human melanocytes against oxidative stress needs to be further studied. Here, we investigated the potential protective effect and mechanisms of ASA against H2O2‐induced oxidative injury in human melanocytes. Human melanocytes were pre‐treated with different concentrations of ASA, followed by exposure to 1.0 mM H2O2. Ce...
Source: Journal of Cellular and Molecular Medicine - March 9, 2016 Category: Molecular Biology Authors: Zhe Jian, Lingzhen Tang, Xiuli Yi, Bangmin Liu, Qian Zhang, Guannan Zhu, Gang Wang, Tianwen Gao, Chunying Li Tags: Original Article Source Type: research