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LncRNA MRAK159688 facilitates morphine tolerance by promoting REST-mediated inhibition of mu opioid receptor in rats
Neuropharmacology. 2022 Jan 1;206:108938. doi: 10.1016/j.neuropharm.2021.108938. Online ahead of print.ABSTRACTMorphine tolerance (MT) caused by the long-term use of morphine is a major medical problem. The molecular mechanism of morphine tolerance remains elusive. Here, we established a morphine tolerance model in rats and verified whether the long noncoding RNA (lncRNA) MRAK159688 is involved in morphine tolerance and its specific molecular mechanism. We show the significant upregulation of MRAK159688 expression in the spinal cord of morphine-tolerant rats. Overexpression of MRAK159688 by a lentivirus reduces the analges...
Source: Neuropharmacology - January 4, 2022 Category: Drugs & Pharmacology Authors: Meiling Deng Zengli Zhang Manyu Xing Xia Liang Zhengyiqi Li Jing Wu Shasha Jiang Yingqi Weng Qulian Guo Wangyuan Zou Source Type: research

Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway.
Conclusions: Up-regulation of MEG3 attended to the morphine-caused autophagy of HT22 cells might be through elevating c-fos expression and promoting ERK pathway activation. More experiments are also needed in the future to analyse the influence of other lncRNAs in drug addiction. PMID: 31433241 [PubMed - in process]
Source: Pharmaceutical Biology - August 22, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Role for engagement of β‐arrestin2 by the transactivated EGFR in agonist‐specific regulation of δ receptor activation of ERK1/2
Conclusions and ImplicationsThe δ receptor‐mediated activation of ERK1/2 is via ligand‐specific transactivation of EGFR. This study adds new insights into the mechanism by which δ receptors activate ERK1/2.
Source: British Journal of Pharmacology - September 23, 2015 Category: Drugs & Pharmacology Authors: Le‐Sha Zhang, Yu‐Jun Wang, Yun‐Yue Ju, Gui‐Ying Zan, Chi Xu, Min‐Hua Hong, Yu‐Hua Wang, Zhi‐Qiang Chi, Jing‐Gen Liu Tags: RESEARCH PAPER Source Type: research

Role for engagement of β‐arrestin 2 by the transactivated EGFR in agonist‐specific regulation of δ receptor activation of ERK1/2
Conclusions and Implicationsδ Receptor‐mediated activation of ERK1/2 is via ligand‐specific transactivation of EGFR. This study gains a new insight into the mechanism by which δ receptor activates ERK1/2.
Source: British Journal of Pharmacology - July 25, 2015 Category: Drugs & Pharmacology Authors: Le‐Sha Zhang, Yu‐Jun Wang, Yun‐Yue Ju, Gui‐Ying Zan, Chi Xu, Min‐Hua Hong, Yu‐Hua Wang, Zhi‐Qiang Chi, Jing‐Gen Liu Tags: RESEARCH PAPER Source Type: research

Different Mechanisms of Homologous and Heterologous μ‐Opioid Receptor Phosphorylation
Abstract The efficiency of μ‐opioid receptor (MOR) signaling is tightly regulated and ultimately limited by the coordinated phosphorylation of intracellular serine and threonine residues. Here, we review and discuss recent progress in the generation and application of phosphosite‐specific MOR antibodies, which have proved to be excellent tools for monitoring the spatial and temporal dynamics of receptor phosphorylation and dephosphorylation. Agonist‐induced phosphorylation of MOR occurs at a conserved 10 residue sequence 370TREHPSTANT379 in the receptor's carboxyl‐terminal cytoplasmic tail. Diverse opioids induce ...
Source: British Journal of Pharmacology - February 12, 2014 Category: Drugs & Pharmacology Authors: Anika Mann, Susann Illing, Elke Miess, Stefan Schulz Tags: Review Article – Opioids: New Pathways to Functional Selectivity – Special issue opioids from INRC meeting Themed Issue Source Type: research

G protein‐gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites
Conclusion and ImplicationsThese results demonstrate that KIR3.1 channels play a primary role in the antinociceptive effects of oxycodone, but not those of morphine, at supraspinal sites and suggest that supraspinal KIR3.1 channels are responsible for the unique analgesic profile of oxycodone.
Source: British Journal of Pharmacology - December 10, 2013 Category: Drugs & Pharmacology Authors: Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa Tags: RESEARCH PAPER Source Type: research

Heterologous Regulation of Agonist‐Independent μ‐Opioid Receptor Phosphorylation by Protein Kinase C
Conclusions & ImplicationsThe present results unravel novel mechanisms of heterologous regulation of MOR phosphorylation by PKC. These findings represent a useful starting point for definitive experiments elucidating the exact contribution of PKC‐driven MOR phosphorylation to diminished MOR responsiveness in morphine tolerance and pathological pain.
Source: British Journal of Pharmacology - December 6, 2013 Category: Drugs & Pharmacology Authors: Susann Illing, Anika Mann, Stefan Schulz Tags: Research Paper Source Type: research

G protein‐gated inwardly rectifying potassium (GIRK) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites
Conclusion and ImplicationsThe results demonstrated that GIRK1 channels play a primary role in the antinociceptive effects of oxycodone, but not morphine, at supraspinal sites, and suggested that supraspinal GIRK1 channels are responsible for the unique analgesic profile of oxycodone.
Source: British Journal of Pharmacology - October 7, 2013 Category: Drugs & Pharmacology Authors: Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa Tags: Research Paper Source Type: research