Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway.

Conclusions: Up-regulation of MEG3 attended to the morphine-caused autophagy of HT22 cells might be through elevating c-fos expression and promoting ERK pathway activation. More experiments are also needed in the future to analyse the influence of other lncRNAs in drug addiction. PMID: 31433241 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

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An independent expert panel to the U.S. Food and Drug Administration on Wednesday recommended approval of GlaxoSmithKline Plc's over-the-counter nicotine oral spray that aims to help smokers quit their addiction.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
By STUART H. SMITH Imagine a massive public health crisis in the United States that affects tens of thousands of people. Now imagine that the government had a simple tool at its disposal that could prevent this kind of physical and psychological trauma. You might think that I’m writing about America’s deadly outbreak of gun violence, which has made headlines this summer from Dayton to El Paso. But actually I’m talking about a different crisis that affects even more people – all of them children — and which could be sharply reduced with one simple step that lacks the bitter political anim...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Patients Big pharma NAS syndrome Opioid Justice Team Opioid-Dependent Babies Opioids public health Stuart Smith Source Type: blogs
WEDNESDAY, Sept. 18, 2019 -- Addiction and overdose deaths aren't the only consequence of America's opioid epidemic. Cases of a potentially deadly heart infection have risen alarmingly, too, a new study finds. This bacterial infection, called...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Examines how states are using addiction counselors, or substance use disorder (SUD) counselors, to fill the shortage of behavioral health providers in rural areas. Discusses how states offer several paths to obtain SUD counseling credentials.
Source: News stories via the Rural Assistance Center - Category: Rural Health Source Type: news
There has been an 80 per cent increase in the number of prescriptions for powerful nerve drug gabapentin in England since 2013, a study has found.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The end of the 1970s ushered in what became an accepted standard of care for most of medicine and dentistry, including oral and maxillofacial surgery: Hydrocodone with acetaminophen was introduced as Vicodin (Knoll Pharmaceutical Company, Whippany, NJ) in 1978 and rapidly embraced by providers to treat all types of pain. Curiously, centuries-old concerns about opioid addiction were largely set aside, and hydrocodone-acetaminophen combinations became the most-prescribed drugs in the US by the early 2000s and remain in the top ten.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and neuropsychological effects of opioid use disorder (OUD). Polymorphisms disrupting the opioid and dopamine systems have been associated with increased risk for developing substance use disorders. Molecular imaging studies have revealed how these polymorphisms impact the brain and contribute to cognitive and behavioral differences across individuals. Here, we review the curr...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractGlobally, chronic pain is a major therapeutic challenge and affects more than 15% of the population. As patients with painful terminal diseases may face unbearable pain, there is a need for more potent analgesics. Although opioid-based therapeutic agents received attention to manage severe pain, their adverse drug effects and mortality rate associated with opioids overdose are the major concerns. Evidences from clinical trials showed therapeutic benefits of cannabis, especially delta-9-tetrahydrocannabinol and cannabinoids reduced neuropathic pain intensity in various conditions. Also, there are reports on using co...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Internet addiction (IA) has become a global mental and social problem, which may lead to a series of psychiatric symptoms including uncontrolled use of internet, and lack of concentration. However, the exact pathophysiology of IA remains unclear. Most of functional connectivity studies were based on pre-selected regions of interest (ROI), which could not provide a comprehensive picture of the communication abnormalities in IA, and might lead to limited or bias observations. Using local functional connectivity density (lFCD), this study aimed to explore the whole-brain abnormalities of functional connectivity in IA. We eval...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Discussion: Therapy for problematic smartphone use should be carried out in light of patient’s attachment style. Further research into other factors of mental stress and personality is needed to better understand problematic smartphone use.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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