• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Electrical field stimulation induces cardiac fibroblast proliferation through the calcineurin-NFAT pathway.
Abstract Most cardiac diseases are associated with fibrosis. Calcineurin (CaN) is regulated by Ca(2+)/calmodulin (CaM). The CaN-NFAT (nuclear factor of activated T cell) pathway is involved in the process of cardiac diseases, such as cardiac hypertrophy, but its effect on myocardial fibrosis remains unclear. The present study investigates whether the CaN-NFAT pathway is involved in cardiac fibroblast (CF) proliferation induced by electrical field stimulation (EFS), which recently became a popular treatment for heart failure and cardiac tissue engineering. CF proliferation was evaluated by a cell survival assay (MT...
Source: Canadian Journal of Physiology and Pharmacology - December 1, 2012 Category: Drugs & Pharmacology Authors: Chen QQ, Zhang W, Chen XF, Bao YJ, Wang J, Zhu WZ Tags: Can J Physiol Pharmacol Source Type: research