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Cigarette smoke extract inhibits cell migration and contraction via the reactive oxygen species/adenosine monophosphate –activated protein kinase pathway in nasal fibroblasts
ConclusionCSE has an inhibitory effect on cell migration and collagen gel contraction activity via the ROS/AMPK signaling pathway in nasal fibroblasts.
Source: International Forum of Allergy and Rhinology - November 5, 2019 Category: Allergy & Immunology Authors: Jae ‐Min Shin, Joo‐Hoo Park, Hyun‐Woo Yang, Heung‐Man Lee, Il‐Ho Park Tags: ORIGINAL ARTICLE Source Type: research

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research