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Cancer: Epithelial Cancer
Drug: Carisoprodol
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Cancers, Vol. 13, Pages 82: STAT3 Stabilizes IKK α Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells
In this study, we observed overexpression and co-localization of IKKα and STAT3 in human breast cancer tissues as well as in H-Ras transformed human breast epithelial (H-Ras MCF-10A) and breast cancer (MDA-MB-231) cells. By utilizing small interfering RNA (siRNA) technology, we were able to demonstrate that STAT3 up-regulated IKKα, but not IKKβ or IKKγ, in these cells. This was attributable to direct binding to and subsequent stabilization of IKKα protein by blocking the ubiquitin-proteasome system. Notably, we identified the lysine 44 residue of IKK&...
Source: Cancers - December 30, 2020 Category: Cancer & Oncology Authors: Young-Il Hahn Soma Saeidi Su-Jung Kim Se-Young Park Na-Young Song Jie Zheng Do-Hee Kim Han-Byoel Lee Wonshik Han Dong-Young Noh Hye-Kyung Na Young-Joon Surh Tags: Article Source Type: research
