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Specialty: Toxicology
Drug: Amphetamine

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Total 4 results found since Jan 2013.

Methamphetamine mediates apoptosis of vascular smooth muscle cells via the Chop-related endoplasmic reticulum stress pathway
We examined the expression of the apoptosis-related proteins Caspase 3 and PARP after METH treatment in vivo and in vitro and detected the expression of endoplasmic reticulum stress-related proteins. After treatment with the endoplasmic reticulum stress inhibitor 4-PBA, changes in the above indicators were examined. C/EBP homologous protein (Chop) expression was also detected, and the relationship between endoplasmic reticulum stress and apoptosis was further determined by siRNA silencing of Chop. The results indicated that METH can induce apoptosis of vascular smooth muscle cells (VSMCs) and upregulate the expression of C...
Source: Toxicology Letters - July 2, 2021 Category: Toxicology Authors: Xiaohui Tan Dunpeng Cai Na Chen Sihao Du Dongfang Qiao Xia Yue Tao Wang Jia Li Weibing Xie Huijun Wang Source Type: research

DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes.
Abstract Methamphetamine (METH) is an amphetamine-like psychostimulant that is commonly abused. Previous studies have shown that METH can induce damages to the nervous system and recent studies suggest that METH can also cause adverse and potentially lethal effects on the cardiovascular system. Recently, we demonstrated that DNA damage-inducible transcript 4 (DDIT4) regulates METH-induced neurotoxicity. However, the role of DDIT4 in METH-induced cardiotoxicity remains unknown. We hypothesized that DDIT4 may mediate METH-induced autophagy and apoptosis in cardiomyocytes. To test the hypothesis, we examined DDIT4 pr...
Source: Toxicology and Applied Pharmacology - January 26, 2016 Category: Toxicology Authors: Chen R, Wang B, Chen L, Cai D, Li B, Chen C, Huang E, Liu C, Lin Z, Xie WB, Wang H Tags: Toxicol Appl Pharmacol Source Type: research