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Metformin attenuates angiotensin II ‐induced TGFβ1 expression by targeting hepatocyte nuclear factor 4α
Conclusions and ImplicationsHNF4α mediated AngII‐induced TGFβ1 transcription and cardiac fibrosis. Metformin inhibited AngII‐induced HNF4α expression via AMPK activation, thus decreasing TGFβ1 transcription and cardiac fibrosis. These findings reveal a novel antifibrotic mechanism of action of metformin and identify HNF4α as a new potential therapeutic target for cardiac fibrosis.
Source: British Journal of Pharmacology - February 23, 2017 Category: Drugs & Pharmacology Authors: Ruifei Chen, Yenan Feng, Jimin Wu, Yao Song, Hao Li, Qiang Shen, Dan Li, Jianshu Zhang, Zhizhen Lu, Han Xiao, Youyi Zhang Tags: RESEARCH PAPER THEMED ISSUE Source Type: research

Metformin induces PGC‐1α expression and selectively affects hepatic PGC‐1α functions
Conclusions and ImplicationsDownregulation of PGC‐1α is not necessary for suppression of gluconeogenic genes by metformin. Importantly, metformin selectively regulates hepatic PGC‐1α‐mediated gene regulation and prevents activation of gluconeogenesis, but leaves regulation of mitochondrial genes intact. Our results thus identify selective modulation of hepatic PGC‐1α functions as a novel mechanism involved in the therapeutic action of metformin.
Source: British Journal of Pharmacology - January 16, 2014 Category: Drugs & Pharmacology Authors: Sanna‐Mari Aatsinki, Marcin Buler, Henriikka Salomäki, Markku Koulu, Petr Pavek, Jukka Hakkola Tags: Research Paper Source Type: research