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Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate.
Abstract People with diabetes mellitus have shorter telomeres compared with non-diabetic subjects. The aim of this study was to investigate an in-vitro model of telomere shortening under diabetes metabolic conditions. The mechanisms of the accelerated telomere length attrition and the potential telomere protective action of fenofibrate with related cellular mechanisms were also examined. Human dermal fibroblasts were passaged and cultured in normal (5.5 mM) or high (25 mM) D-glucose, across 7 days with hydrogen peroxide (H2O2), glucosamine (GA), or glycated albumin (AGEs-BSA). Relative telomere length (RTL) was...
Source: Journal of Cell Communication and Signaling - June 14, 2019 Category: Molecular Biology Authors: Sutanto SSI, McLennan SV, Keech AC, Twigg SM Tags: J Cell Commun Signal Source Type: research

Effects of short‐chain acyl‐CoA dehydrogenase on cardiomyocyte apoptosis
In conclusion, for the first time our findings directly demonstrated that SCAD may be as a new target to prevent cardiomyocyte apoptosis through the AMPK/PPARα/SCAD signal pathways.
Source: Journal of Cellular and Molecular Medicine - March 17, 2016 Category: Molecular Biology Authors: Zhenhua Zeng, Qiuju Huang, Zhaohui Shu, Peiqing Liu, Shaorui Chen, Xuediao Pan, Linquan Zang, Sigui Zhou Tags: Original Article Source Type: research

Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis.
In conclusion, for the first time our findings directly demonstrated that SCAD may be as a new target to prevent cardiomyocyte apoptosis through the AMPK/PPARα/SCAD signal pathways. PMID: 26989860 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - March 17, 2016 Category: Molecular Biology Authors: Zeng Z, Huang Q, Shu Z, Liu P, Chen S, Pan X, Zang L, Zhou S Tags: J Cell Mol Med Source Type: research

Effects of short ‐chain acyl‐CoA dehydrogenase on cardiomyocyte apoptosis
In conclusion, for the first time our findings directly demonstrated that SCAD may be as a new target to prevent cardiomyocyte apoptosis through the AMPK/PPARα/SCAD signal pathways.
Source: Journal of Cellular and Molecular Medicine - March 16, 2016 Category: Molecular Biology Authors: Zhenhua Zeng, Qiuju Huang, Zhaohui Shu, Peiqing Liu, Shaorui Chen, Xuediao Pan, Linquan Zang, Sigui Zhou Tags: Original Article Source Type: research

Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress.
This study was designed to investigate the expression of short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, during rat heart development and the difference of SCAD between pathological and physiological cardiac hypertrophy. The expression of SCAD was lowest in the foetal and neonatal heart, which had time-dependent increase during normal heart development. In contrast, a significant decrease in SCAD expression was observed in different ages of spontaneously hypertensive rats (SHR). On the other hand, swim-trained rats developed physiological cardiac hypertrophy, whereas SHR developed pathol...
Source: J Cell Mol Med - March 8, 2015 Category: Molecular Biology Authors: Huang J, Xu L, Huang Q, Luo J, Liu P, Chen S, Yuan X, Lu Y, Wang P, Zhou S Tags: J Cell Mol Med Source Type: research

Changes in short‐chain acyl‐coA dehydrogenase during rat cardiac development and stress
This study was designed to investigate the expression of short‐chain acyl‐CoA dehydrogenase (SCAD), a key enzyme of fatty acid β‐oxidation, during rat heart development and the difference of SCAD between pathological and physiological cardiac hypertrophy. The expression of SCAD was lowest in the foetal and neonatal heart, which had time‐dependent increase during normal heart development. In contrast, a significant decrease in SCAD expression was observed in different ages of spontaneously hypertensive rats (SHR). On the other hand, swim‐trained rats developed physiological cardiac hypertrophy, whereas SHR develo...
Source: Journal of Cellular and Molecular Medicine - March 8, 2015 Category: Molecular Biology Authors: Jinxian Huang, Lipeng Xu, Qiuju Huang, Jiani Luo, Peiqing Liu, Shaorui Chen, Xi Yuan, Yao Lu, Ping Wang, Sigui Zhou Tags: Original Article Source Type: research