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Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multi-ligand endocytic receptor megalin.
Abstract The present study tested the hypothesis that the multi-ligand endocytic receptor megalin is partially involved in the uptake of angiotensin II (ANG II) and downstream signaling responses in mouse proximal tubule cells (mPCT) by interacting with AT1a receptors. mPCT cells of wild-type (WT) and AT1a receptor-deficient (AT1a-KO) mice were treated with vehicle, the AT1 receptor blocker losartan (10 µM), or a selective megalin siRNA for 48 h. The uptake of fluorescein (FITC)-labeled ANG II (10 nM, 37(o)C) and downstream signaling responses were analyzed by fluorescence imaging and western blot. AT1a receptors...
Source: Am J Physiol Renal P... - April 16, 2014 Category: Urology & Nephrology Authors: Li XC, Zhuo JL Tags: Am J Physiol Renal Physiol Source Type: research

Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species
Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential‐6 (TRPC6) channels stimulate Ca2+ influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely blocked ...
Source: Journal of Cellular Physiology - December 17, 2013 Category: Cytology Authors: Marc Anderson, Hila Roshanravan, Justin Khine, Stuart E. Dryer Tags: Original Research Article Source Type: research

Angiotensin II activation of canonical transient receptor potential‐6 (TRPC6) channels in rat podocytes requires generation of reactive oxygen species
Abstract Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential‐6 (TRPC6) channels stimulate Ca2+ influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely...
Source: Journal of Cellular Physiology - September 3, 2013 Category: Cytology Authors: Marc Anderson, Hila Roshanravan, Justin Khine, Stuart E. Dryer Tags: Original Research Article Source Type: research

Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts.
Abstract The proliferation of cardiac fibroblasts is implicated in the pathogenesis of myocardial remodeling and fibrosis. Intermediate-conductance calcium-activated K(+) channels (KCa3.1 channels) have important roles in cell proliferation. However, it is unknown whether angiotensin II (Ang II), a potent profibrotic molecule, would regulate KCa3.1 channels in cardiac fibroblasts and participate in cell proliferation. In the present study, we investigated whether KCa3.1 channels were regulated by Ang II, and how the channel activity mediated cell proliferation in cultured adult rat cardiac fibroblasts using electr...
Source: Biochemical Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Wang LP, Wang Y, Zhao LM, Li GR, Deng XL Tags: Biochem Pharmacol Source Type: research

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