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SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma
Conclusions: Combined, our findings highlight a tumor-promoting role for SLC39A6 in ESCC, suggesting that SLC39A6 could serve as an early detector of high-risk subjects and prognostic biomarker. The targeting of SLC39A6 might be a potential therapeutic strategy for blocking ESCC.
Source: Journal of Translational Medicine - October 6, 2015 Category: Research Authors: Xiao-Bin CuiYao-yuan ShenTing-ting JinSu LiTing-ting LiShu-mao ZhangHao PengChun-xia LiuShu-gang LiLan YangNa LiJian-ming HuJin-Fang JiangMan LiWei-hua LiangYong LiYu-tao WeiZhen-zhu SunChuan-yue WuYun-Zhao ChenFeng Li Source Type: research

M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh’s ESCC and promotes proliferation and migration of ESCC cells
The objectives of the present study are to explore role of pyruvate kinase isoenzyme type M2 (PKM2) in progression of Kazakh’s esophageal squamous cell carcinoma (ESCC) in Xinjiang, China, and to clarify mechanism of PKM2 in malignant phenotype. PKM2 expression was examined using immunohistochemistry (IHC) in 101 matched pairs of ESCC and normal adjacent tissues (NATs) and using enzyme-linked immunosorbent assay (ELISA) in 35 serum samples of Kazakh’s ESCC and 8 serum samples of healthy subjects. To investigate mechanism, small interfering RNA (siRNA)-PKM2 was transfected into ESCC cells. Cell migration and invasion we...
Source: Tumor Biology - September 24, 2015 Category: Cancer & Oncology Source Type: research