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High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling
This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell f...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/ β‐catenin signaling
This study has demonstrated that ras homolog family member A (RhoA), along with its major effector, Rho ‐associated kinases 1 (ROCK1) activates β‐catenin signaling to promote osteogenic differentiation and restrain adipogenic differentiation. Lysophosphatidic acid (LPA) receptor 4 (LPAR4), one of the receptors of LPA, blocks the activation of RhoA/ROCK1/β‐catenin signaling pathway, and thereby reciprocally regulates osteogenic and adipogenic differentiation of mesenchymal progenitor cellsin vitro andin vivo. The study suggests the potential of LPAR4 as a pharmaceutical target to treat metabolic disorders such as osteoporosis.
Source: Stem Cells - November 27, 2019 Category: Stem Cells Authors: Yan Xie, Xiaochen Wang, Xiaowen Wu, Lijie Tian, Jie Zhou, Xiaoxia Li, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2 ‐Mediated Degradation of p53
Abstract Bre is a conserved cellular protein expressed in various tissues. Its major function includes DNA damage repair and anti‐apoptosis. Recent studies indicate that Bre is potentially involved in stem cell differentiation although pathophysiological significance along with the molecular mechanisms is still unclear. Here, we report that Bre protein was substantially expressed in the bone tissue and its expression was highly upregulated during the osteogenic differentiation. To test a hypothesis that Bre plays functional roles in the process of osteogenic differentiation, we examined the expression of Bre in an osteop...
Source: Stem Cells - April 24, 2017 Category: Stem Cells Authors: Fujun Jin, Yiliang Wang, Xiaojing Wang, Yanting Wu, Xiaoyan Wang, Qiuying Liu, Yexuan Zhu, Enqi Liu, Jianglin Fan, Yifei Wang Tags: Tissue ‐Specific Stem Cells Source Type: research