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Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research

Secreted PLA < sub > 2 < /sub > -III is a possible therapeutic target to treat neuropathic pain
Biochem Biophys Res Commun. 2021 Jul 5;568:167-173. doi: 10.1016/j.bbrc.2021.06.058. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) plays a critical role in developing and maintaining chronic pain in various animal models. Previous studies have reported that cytosolic and calcium-independent phospholipase A2 (PLA2) is involved in the LPA receptor-mediated amplification of LPA production in the spinal dorsal horn (SDH) after nerve injury, while the involvement of secreted PLA2 (sPLA2) remains unclear. The present study revealed that only sPLA2 -III among 11 species of PLA2 showed a significant upregulation of gen...
Source: Biochemical and Biophysical Research communications - July 8, 2021 Category: Biochemistry Authors: Keigo Tanaka Naoki Dozono Hiroyuki Neyama Jun Nagai Ryoko Tsukahara Kazuki Nagayasu Shuji Kaneko Hiroshi Ueda Source Type: research

Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis.
This article is protected by copyright. All rights reserved. PMID: 24860175 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - May 23, 2014 Category: Physiology Authors: Xia J, Pan R, Gao X, Meucci O, Hu H Tags: J Physiol Source Type: research