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Network Pharmacology-Based Strategy to Investigate the Mechanisms of < em > Cibotium barometz < /em > in Treating Osteoarthritis
Evid Based Complement Alternat Med. 2022 Jul 14;2022:1826299. doi: 10.1155/2022/1826299. eCollection 2022.ABSTRACTCibotium barometz is a representative tonifying kidney drug and is widely used for osteoarthritis (OA) in traditional Chinese medicine. However, its regulatory mechanisms in treating OA remain to be sufficiently investigated. The main chemical components of Cibotium barometz were screened through the TCMID database and the corresponding targets were acquired through SwissTargetPrediction. The OA-related targets were obtained from the OMIM, Genecards, Genebank, TTD, and DisGeNET databases. The prediction of key ...
Source: Evidence-based Complementary and Alternative Medicine - July 25, 2022 Category: Complementary Medicine Authors: Guang-Yao Chen Yi-Fei Wang Xin-Bo Yu Xiao-Yu Liu Jia-Qi Chen Jing Luo Qing-Wen Tao Source Type: research

Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF- < em > κB < /em > and PI3K/AKT Pathways
In conclusion, TFRD showed chondroprotective effects by restoring the MMP/TIMP balance in OA models by suppressing the activation of the NF-κB and PI3K/AKT pathways.PMID:33995548 | PMC:PMC8081598 | DOI:10.1155/2021/6634837
Source: Evidence-based Complementary and Alternative Medicine - May 17, 2021 Category: Complementary Medicine Authors: Guang-Yao Chen Jia-Qi Chen Xiao-Yu Liu Yuan Xu Jing Luo Yi-Fei Wang Tong-Liang Zhou Ze-Ran Yan Li Zhou Qing-Wen Tao Source Type: research

Effect of Gubi prescription on caveolin-1 expression and phosphoinositide 3 kinase/protein kinase B and Fas signal pathways in rats with knee osteoarthritis.
CONCLUSION: Gubi prescription suppressed the chondrocyte-related PI3K/Akt and Fas signal pathways and inhibited the overexpression of caveolin-1 in rat chondrocytes. PMID: 32242388 [PubMed - in process]
Source: Journal of Traditional Chinese Medicine - March 31, 2020 Category: Complementary Medicine Authors: He X, Zhou X, Xu L, Cao J, Wang R, Wang M, Xie G, Wang L Tags: J Tradit Chin Med Source Type: research