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Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research

Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research

MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain
In conclusion, in the present study, it was shown that MAGL regulated synovial macrophage polarization by inhibiting mitophagy in OA.PMID:37144506 | DOI:10.3892/mmr.2023.13004
Source: Molecular Medicine - May 5, 2023 Category: Molecular Biology Authors: Chengyong Gu Mo Chen Xueyan Li Dechun Geng Chen Wang Source Type: research

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