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Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway.
In conclusion, ZSHLF inhibits the downstream EGFR/ERK signaling pathway by blocking the striatin-mediated membrane localization of MR, which may be an important molecular mechanism by which ZSHLF improves aldosterone-induced myocardial remodeling. PMID: 33014117 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - October 7, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway
Conclusions: Taken together, these results suggest that a NOX4-dependent pathway plays an important role in regulating the inhibitory effect of QYGS. Our findings provide new insights into the molecular mechanisms of QYYYG and their role in the treatment of hypertensive nephropathy.
Source: BMC Complementary and Alternative Medicine - March 25, 2015 Category: Complementary Medicine Authors: Kang DingYan WangWeimin JiangYu ZhangHongping YinZhuyuan Fang Source Type: research