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Abstract P162: Nicotine via Cd36, Cox2 and Oxidative Stress Promotes Podocyte Injury: Link Between E-cigarettes and Renal Disease Progression? Session Title: Chronic Kidney and Renal
Conclusion: NIC activated in human POD a reciprocal interplay between NADPH oxidases and COX2 that increased O2- production, reduced Synpo and upregulated the B scavenger receptor CD36 that, via increased uptake of oxidized LDL, promoted podocyte apoptosis. We surmise that these novel findings implicate NIC as a risk factor for CVD and CKD progression.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Raij, L., Tian, R., Zhou, M.-S. Tags: Session Title: Chronic Kidney and Renal Source Type: research

Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle
In this study, we demonstrated that chronic CS exposure led to rat weight loss, right ventricular hypertrophy, and pulmonary arterial remodeling. A fluorescence microscope was used to measure intracellular calcium concentration ([Ca2+]i) in rat distal PASMCs. Results showed that basal [Ca2+]i and store-operated calcium entry (SOCE) levels in PASMCs from 3- and 6-mo CS-exposed rats were markedly higher than those in cells from the unexposed control animals (the increases in 6-mo CS group were more significant than that in 3-mo group), accompanied with increased canonical transient receptor potential 1 (TRPC1) and TRPC6 expr...
Source: AJP: Cell Physiology - February 15, 2014 Category: Cytology Authors: Wang, J., Chen, Y., Lin, C., Jia, J., Tian, L., Yang, K., Zhao, L., Lai, N., Jiang, Q., Sun, Y., Zhong, N., Ran, P., Lu, W. Tags: ARTICLES Source Type: research

Effect of Chronic Exposure to Cigarette Smoke on Canonical Transient Receptor Potential Expression in Rat Pulmonary Arterial Smooth Muscle.
In this study, we demonstrated that chronic cigarette smoke (CS) exposure leads to rat weight loss, right ventricular hypertrophy, and pulmonary artery remodeling. A fluorescence microscope was used to measure intracellular calcium concentration ([Ca(2+)]i) in rat distal PASMCs. Results showed that basal [Ca(2+)]i and store-operated calcium entry (SOCE) level in PASMCs from 3 and 6 months CS exposed rats were higher than those in the unexposed control group, among which the increase in 6 months CS group was more significant than that in 3 months group. Furthermore, chronic exposure to CS also increased TRPC1 and TRPC6 expr...
Source: American Journal of Physiology. Cell Physiology - December 11, 2013 Category: Cytology Authors: Wang J, Chen Y, Lin C, Jia J, Tian L, Yang K, Zhao L, Lai N, Jiang Q, Sun Y, Zhong NS, Ran P, Lu W Tags: Am J Physiol Cell Physiol Source Type: research