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Peroxisome proliferator-activated receptor-{gamma} enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4
Pulmonary hypertension (PH) is a progressive disorder whose cellular pathogenesis involves enhanced smooth muscle cell (SMC) proliferation and resistance to apoptosis signals. Existing evidence demonstrates that the tumor suppressor programmed cell death 4 (PDCD4) affects patterns of cell growth and repair responses in the systemic vasculature following experimental injury. In the current study, the regulation PDCD4 and its functional effects on growth and apoptosis susceptibility in pulmonary artery smooth muscle cells were explored. We previously demonstrated that pharmacological activation of the nuclear transcription f...
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2017 Category: Respiratory Medicine Authors: Green, D. E., Murphy, T. C., Kang, B.-Y., Bedi, B., Yuan, Z., Sadikot, R. T., Hart, C. M. Tags: RESEARCH ARTICLE Source Type: research

Peroxisome Proliferator-Activated Receptor Gamma Enhances Human Pulmonary Artery Smooth Muscle Cell Apoptosis Through MicroRNA-21 and Programmed Cell Death 4.
Abstract Pulmonary hypertension (PH) is a progressive disorder whose cellular pathogenesis involves enhanced smooth muscle cell (SMC) proliferation and resistance to apoptosis signals. Existing evidence demonstrates that the tumor suppressor, programmed cell death 4 (PDCD4) affects patterns of cell growth and repair responses in the systemic vasculature following experimental injury. In the current study, the regulation PDCD4 and its functional effects on growth and apoptosis susceptibility in pulmonary artery smooth muscle cells was explored. We previously demonstrated that pharmacological activation of the nucle...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 18, 2017 Category: Cytology Authors: Green DE, Murphy TC, Kang BY, Bedi B, Yuan Z, Sadikot RT, Hart CM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Peroxisome proliferator-activated receptor γ inhibits pulmonary hypertension targeting store-operated calcium entry
In this study, we investigated the role of peroxisome proliferator-activated receptor γ (PPARγ) on store-operated calcium entry (SOCE) and expression of the main store-operated calcium channel (SOCCs) components, canonical transient receptor potential (TRPC) in chronic hypoxia (CH)-induced pulmonary hypertension (CHPH) rat models. Small interfering RNA (siRNA) knockdown and adenoviral overexpression strategies were constructed for loss-of-function and gain-of-function experiments. PPARγ agonist rosiglitazone attenuates the pathogenesis of CHPH and suppresses Hif-1α, TRPC1, TRPC6 expression in the distal pulmonary arter...
Source: Journal of Molecular Medicine - November 14, 2014 Category: Molecular Biology Source Type: research