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Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity
CONCLUSIONS: Variants of the rs4435111 and rs2755237 loci in the FOXO1 gene were associated with susceptibility to ATDH. Coadministration of INH/RIF promoted the transfer of FOXO1 from the cytoplasm to the nucleus, but the functional significance of its nuclear translocation requires further verification.PMID:34249128 | PMC:PMC8238576 | DOI:10.1155/2021/3185874
Source: Evidence-based Complementary and Alternative Medicine - July 12, 2021 Category: Complementary Medicine Authors: Jingwei Zhang Lin Jiao Jiajia Song Tao Wu Hao Bai Tangyuheng Liu Zhenzhen Zhao Xuejiao Hu Binwu Ying Source Type: research

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses
The objective of this study was to explore the role of NOD2 and TLR2 in cross-presentation in human dendritic cells undertaking an unbiased screen. We have used a quantitative phosphoproteomic analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) followed by a computational analysis to identify the proteins as differentially abundant in response to NOD2 and TLR2 sensing. Validation of the phosphoproteomic analysis was performed by the detection of proteins in phosphoenriched lysates and detected by western blot. Techniques for the modulation of gene expression (shRNA and siRNA) were used to confirm the resu...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Mycobacterium tuberculosis primarily infects lung macrophages. However, a recent study showed that M. tuberculosis also infects and persists in a dormant form inside bone marrow mesenchymal stem cells (BM-MSCs) even after successful antibiotic therapy. However, the mechanism(s) by which M. tuberculosis survives in BM-MSCs is still not known. Like macrophages, BM-MSCs do not contain a well-defined endocytic pathway, which is known to play a central role in the clearance of internalized mycobacteria. Here, we studied the fate of virulent and avirulent mycobacteria in Sca-1+ CD44+ BM-MSCs. We found that BM-MSCs were able to k...
Source: Infection and Immunity - September 20, 2017 Category: Infectious Diseases Authors: Naik, S. K., Padhi, A., Ganguli, G., Sengupta, S., Pati, S., Das, D., Sonawane, A. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research

Forkhead box O3 (FOXO3) Transcription Factor mediates Apoptosis in BCG‐Infected Macrophages
Summary Enhanced apoptosis of BCG‐infected macrophages has been shown to induce stronger dendritic cell‐mediated cross‐priming of T cells, leading to higher protection against Tuberculosis (TB). Uncovering host effectors underlying BCG‐induced apoptosis may then prove useful to improve BCG efficacy through priming macrophage apoptosis. Her we report that BCG‐mediated apoptosis of human macrophages relies on FOXO3 transcription factor activation. BCG induced a significant apoptosis of THP1 (TDMs) and human monocytes (MDMs)‐derived macrophages when a high MOI was used, as shown by annexin V/7‐AAD staining. BCG�...
Source: Cellular Microbiology - April 1, 2014 Category: Microbiology Authors: Meriam Haoues, Amira Refai, Aude Mallavialle, M.Ridha Barbouche, Nizar Laabidi, Marcel Deckert, Makram Essafi Tags: Research Article Source Type: research